Prospective study of alcohol drinking coronary heart disease in women and patterns and men
Prospective study of alcohol drinking coronary heart disease in women and patterns and men
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DOI：
10.1136/bmj.38831.503113.7c
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发表时间：
2006-05-27
影响因子：
105.7
通讯作者：
Gronbæk, Morten
中科院分区：
文献类型：
--
作者：
Tolstrup, Janne;Jensen, Majken K.;Gronbæk, Morten
目的确定女性和男性饮酒模式与冠心病风险之间的关系。设计基于人群的队列研究。背景丹麦，1993-2002年。参与者28448名女性和25052名男性，年龄在50-65岁之间，在进入研究时无心血管疾病。主要结果测量在中位随访期5.7年期间发生的冠心病发病率。每周至少有一天饮酒的女性患冠心病的风险低于每周饮酒少于一天的女性。然而，饮酒频率之间的差异很小：每周一天（风险比0.64，95%置信区间0.51至0.81），每周2-4天（0.63，0.52至0.77），每周5或6天（0.79，0.61至1.03）和每周7天（0.65，0.51至0.84）。对于男性来说，在整个饮酒频率范围内，饮酒频率与冠心病风险之间存在负相关。最低的风险是观察男性谁每天喝酒（0.59，0.48至0.71）相比，男性谁喝了酒精少于一天一week.Conclusions女性饮酒量可能是主要的决定因素之间的负相关饮酒和冠心病的风险，而在男性中，饮酒频率，而不是酒精摄入量，似乎更重要。
Objective To determine the association between alcohol drinking patterns and risk of coronary heart disease in women and men.Design Population based cohort study.Setting Denmark, 1993-2002..Participants 28 448 women and 25 052 men aged 50-65 years, who were free of cardiovascular disease at entry to the study.Main outcome measures Incidence of coronary heart disease occurring during a median follow-up period of 5.7 years.Results 749 and 1283 coronary heart disease events occurred among women and men. Women who drank alcohol on at least one day a week had a lower risk of coronary heart disease than women who drank alcohol on less than one day a week. Little difference was found, however, between drinking frequency: one day a week (hazard ratio 0.64, 95% confidence interval 0.51 to 0.81), 2-4 days a week (0.63, 0.52 to 0.77), five or six days a week (0.79, 0.61 to 1.03), and seven days a week (0.65, 0.51 to 0.84). For men an inverse association was found between drinking frequency and risk of coronary heart disease across the entire range of drinking frequencies. The lowest risk was observed among men who drank daily (0.59, 0.48 to 0.71) compared with men who drank alcohol on less than one day a week.Conclusions Among women alcohol intake may be the primary determinant of the inverse association between drinking alcohol and risk of coronary heart disease whereas among men, drinking frequency, not alcohol intake, seems more important.