Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH‐Responsive Theranostic Platform
Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH‐Responsive Theranostic Platform
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DOI：
10.1002/adfm.201400256
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发表时间：
2014-07
影响因子：
19
通讯作者：
Meiying Wu;Qingshuo Meng;Yu Chen;Pengfei Xu;Shengjian Zhang;Yaping Li;Lingxia Zhang;Min Wang
中科院分区：
文献类型：
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作者：
Meiying Wu;Qingshuo Meng;Yu Chen;Pengfei Xu;Shengjian Zhang;Yaping Li;Lingxia Zhang;Min Wang
一种独特的介孔二氧化硅纳米颗粒（MSNs）为基础的治疗平台，将超小氧化铁纳米颗粒（NPs）限制在介孔网络中，采用简单而有效的物理蒸汽渗透（PVI）方法开发。在介孔通道内高度分散的铁可以同时作为无毒的造影剂，用于高效的T1加权MR成像，并作为抗癌药物分子装载和pH响应释放的锚定位点，基于铁与药物分子之间特殊的金属配位键。此外，所获得的Fe - msn具有良好的生物相容性，增强了化疗疗效，同时减少了化疗药物非特异性攻击的副作用，并且在体外和体内具有绕过癌细胞多药耐药（MDR）和抑制肿瘤细胞转移的能力。这种pH响应性治疗剂为未来的生物医学应用提供了一种新的有前途的基于msn的抗癌纳米药物。
A unique mesoporous silica nanoparticles (MSNs)‐based theranostic platform with ultrasmall iron oxide nanoparticles (NPs) confined within mesopore network has been developed by a facile but efficient physical‐vapor‐infiltration (PVI) method. The highly dispersed Fe species within mesopore channels can synchronously function as the non‐toxic contrast agents for highly efficient T1‐weighted MR imaging, and as anchoring sites for anti‐cancer drug molecule loading and pH‐responsive release based on the special metal‐ligand coordination bonding between the Fe species and drug molecules. Moreover, the obtained Fe‐MSNs exhibit favorable biocompatibility, enhanced chemotherapeutic efficacy and concurrently diminished side effects due to the non‐specific attack of chemotherapeutic drugs, as well as the capability in circumventing the multidrug resistance (MDR) of cancer cells and suppressing the metastasis of tumor cells in vitro and in vivo. This pH‐resoponsive theranostic agent provides a new promising MSNs‐based anti‐cancer nanomedicine for future biomedical application.