Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis.
Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis.
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DOI：
10.3389/fcimb.2021.678945
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发表时间：
2021
影响因子：
5.7
通讯作者：
Elkhidir IM
中科院分区：
文献类型：
--
作者：
Eltom K;Enan K;El Hussein ARM;Elkhidir IM
在过去的几十年里，登革病毒(DENV)感染引起了全球的关注。然而，由于缺乏全面的监测和报告系统，其在某些发展中和低收入地区的流行病学仍然知之甚少。这项系统的回顾和荟萃分析旨在使用DENV感染标志物确定DENV感染在撒哈拉以南非洲人口中的流行率，并跟踪其流行率在过去十年中的任何变化。它是根据PRISMA指南进行的，目标是MEDLINE/PubMed、Science Direct、Cochrane图书馆和Google Scholar上可用的文献。对2010年1月至2020年6月期间发表的所有英文文章进行了资格筛选。采用随机效应模型计算各感染标志物的混合患病率。不一致指数(I2)用于评估研究之间的异质性水平。根据研究的国家和时间框架进行了亚组分析，以提供对显著异质性的可能解释。由乔安娜·布里格斯研究所(JBI)设计的流行研究的关键评估工具被用来评估所有纳入研究中的偏见风险。这篇综述共收录了涉及21个国家的84篇文章。定量Meta分析估计混合免疫球蛋白流行率为2 5%(95%CI：2 1~2 9%，I2=99%)，混合IgM流行率为10%(95%CI：9~11%，I2=98%)，混合DENV RNA流行率为14%(95%CI：12~16%，I2=99%)。在所有三个荟萃分析中也发现了可能存在发表偏倚的证据。根据样本收集时间进行亚组分析，密切跟踪2010至2019年间DENV感染标志物的变化流行情况。这项荟萃分析估计，新城疫病毒在撒哈拉以南非洲的感染率很高。应设计和实施更具成本效益的病媒控制战略，以适应该区域资源不足的特点。
Dengue virus (DENV) infection has garnered a global interest in the past few decades. Nevertheless, its epidemiology in certain developing and low-income regions remains poorly understood, due to the absence of comprehensive surveillance and reporting systems. This systematic review and meta-analysis aimed to determine the prevalence of DENV infection in the population of Sub-Saharan Africa using DENV infection markers, and to track any changes in its prevalence during the past ten years. It was conducted in accordance with the PRISMA guidelines, targeting the literature available at MEDLINE/PubMed, ScienceDirect, Cochrane library and Google Scholar. All articles published in English language between January 2010 and June 2020 were screened for eligibility. Random effects model was used to calculate the pooled prevalence of all infection markers. The Inconsistency Index (I 2) was used to assess the level of heterogeneity between studies. Subgroup analysis according to country and time-frame of studies was conducted to provide possible explanations to substantial heterogeneity. The critical appraisal tool for prevalence studies designed by the Joanna Briggs Institute (JBI) was used to assess the risk of bias in all included studies. A total of 84 articles, covering 21 countries, were included in this review. Quantitative meta-analysis estimated a pooled IgG prevalence of 25% (95% CI: 21-29%, I 2 = 99%), a pooled IgM prevalence of 10% (95% CI: 9-11%, I 2 = 98%) and a pooled DENV RNA prevalence of 14% (95% CI: 12-16%, I 2 = 99%). Evidence for possible publication bias was also found in all three meta-analyses. Subgroup analysis according to the time of sample collection was performed to closely track the changing prevalence of DENV infection markers between 2010 and 2019. This meta-analysis estimates a high prevalence of DENV infection in Sub-Saharan Africa. More cost-efficient vector control strategies should be designed and implemented in order to adapt to the low-resource nature of this region.