Beneficial effects of subcutaneous fat transplantation on metabolism
Beneficial effects of subcutaneous fat transplantation on metabolism
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DOI：
10.1016/j.cmet.2008.04.004
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发表时间：
2008-05-01
期刊：
影响因子：
29
通讯作者：
Kahn, C. Ronald
中科院分区：
文献类型：
--
作者：
Tran, Thien T.;Yamamoto, Yuji;Kahn, C. Ronald
皮下（SC）和内脏（维斯）肥胖与糖尿病和代谢综合征的不同风险相关。为了阐明这些差异是否是由于解剖位置或内在的脂肪库的差异，我们的特点移植SC或维斯脂肪从供体小鼠到SC或维斯区受体小鼠后的小鼠。将SC脂肪移植到维斯腔中的组表现出体重、总脂肪量以及葡萄糖和胰岛素水平降低。这些小鼠在高胰岛素-正常血糖钳夹期间也表现出胰岛素敏感性改善，全身葡萄糖摄取增加，葡萄糖摄取进入内源性脂肪，胰岛素抑制肝脏葡萄糖产生。将SC脂肪移植到SC区域观察到的这些效应程度较低，而将维斯脂肪移植到维斯区域则没有效应。这些数据表明，SC脂肪本质上不同于维斯脂肪，并产生可全身作用以改善葡萄糖代谢的物质。
Subcutaneous (SC) and visceral (VIS) obesity are associated with different risks of diabetes and the metabolic syndrome. To elucidate whether these differences are due to anatomic location or intrinsic differences in adipose depots, we characterized mice after transplantation of SC or VIS fat from donor mice into either SC or VIS regions of recipient mice. The group with SC fat transplanted into the VIS cavity exhibited decreased body weight, total fat mass, and glucose and insulin levels. These mice also exhibited improved insulin sensitivity during hyperinsulinemic-euglycemic clamps with increased whole-body glucose uptake, glucose uptake into endogenous fat, and insulin suppression of hepatic glucose production. These effects were observed to a lesser extent with SC fat transplanted to the SC area, whereas VIS fat transplanted to the VIS area was without effect. These data suggest that SC fat is intrinsically different from VIS fat and produces substances that can act systemically to improve glucose metabolism.