Spotlight on New Therapeutic Opportunities for MYC-Driven Cancers.
Spotlight on New Therapeutic Opportunities for MYC-Driven Cancers.
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DOI：
10.2147/ott.s366627
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发表时间：
2023
影响因子：
4
通讯作者：
Riches, John C.
中科院分区：
文献类型：
--
作者：
D'Avola, Annalisa;Kluckova, Katarina;Finch, Andrew J.;Riches, John C.
MYC可以被认为是开发新型抗癌疗法最紧迫和最重要的靶点之一。这是由于其在肿瘤中的频繁失调，以及这种失调对基因表达和细胞行为的广泛影响。因此，在过去的几十年里，有许多针对MYC的尝试，无论是直接的还是间接的，结果好坏参半。本文综述了MYC在癌症和药物开发中的生物学作用。它讨论了直接靶向MYC的策略，包括旨在降低其表达和阻断其功能的策略。此外，还概述了MYC失调对细胞生物学的影响，以及如何理解这一点可以支持针对MYC调节的分子和途径的方法的发展。该综述特别关注MYC在代谢调节中的作用，以及通过抑制代谢途径提供的治疗途径，这些途径对MYC转化细胞的存活至关重要。
MYC can be considered to be one of the most pressing and important targets for the development of novel anti-cancer therapies. This is due to its frequent dysregulation in tumors and due to the wide-ranging impact this dysregulation has on gene expression and cellular behavior. As a result, there have been numerous attempts to target MYC over the last few decades, both directly and indirectly, with mixed results. This article reviews the biology of MYC in the context of cancers and drug development. It discusses strategies aimed at targeting MYC directly, including those aimed at reducing its expression and blocking its function. In addition, the impact of MYC dysregulation on cellular biology is outlined, and how understanding this can underpin the development of approaches aimed at molecules and pathways regulated by MYC. In particular, the review focuses on the role that MYC plays in the regulation of metabolism, and the therapeutic avenues offered by inhibiting the metabolic pathways that are essential for the survival of MYC-transformed cells.