Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression
Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression
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DOI：
10.1016/j.jad.2011.02.024
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发表时间：
2011-07-01
影响因子：
6.6
通讯作者：
Smeraldi, Enrico
中科院分区：
文献类型：
--
作者：
Benedetti, Francesco;Radaelli, Daniele;Smeraldi, Enrico
在动物中，5-HT 1A受体的高密度与压力后行为绝望的增加有关。在人类中，C（-1019）G 5-HT 1A受体启动子基因多态性（rs6295）的G变体与5-HT 1A受体的高表达、抑郁症的增加和自杀前的低压力相关。目的：我们研究了rs6295与双相情感障碍患者早期生活中的压力和因重度抑郁发作住院前的压力之间的关系。disorder.材料和方法：在74个连续入院的住院患者，早期生活和最近的压力源被评为社会再适应评定量表和Risky Family Questionnaire.Results：rs6295 G变异的纯合子携带者报告的压力较小的事件之前，目前住院治疗双相抑郁症，但不是在早期生活。G变异体也与更高的整体药物负荷在naturalistic settings before hospitalization.Conclusions：这是第一项研究，相关的5-HT 1A受体启动子基因的变异体与压力因素之前，需要住院治疗双相抑郁症。我们的研究结果支持了这一假设，即遗传因素影响神经递质可能有助于塑造个人的弹性抑郁症的压力在临床环境中的影响。(C)2011 Elsevier B. V.保留所有权利。
Rationale: In animals, a higher density of 5-HT1A receptors has been associated with increased behavioral despair after stress. In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.Objectives: We studied the association of rs6295 with the amount of stress in early life and preceding hospitalization for a major depressive episode in course of bipolar disorder.Materials and methods: In 74 consecutively admitted inpatients, early life and recent stressors were rated on the Social Readjustment Rating Scale and on the Risky Family Questionnaire.Results: Homozygote carriers of the rs6295 G variant reported less stressful events before current hospitalization for bipolar depression, but not in early life. The G variant was also associated with a higher overall medication load in naturalistic settings before hospitalization.Conclusions: This is the first study that associated 5-HT1A receptor promoter gene variants with stressors preceding the need of hospitalization for bipolar depression. Our findings support the hypothesis that genetic factors affecting serotonergic neurotransmission might contribute to shape the individual resilience to the depressogenic effects of stress in clinical settings. (C) 2011 Elsevier B.V. All rights reserved.