Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.
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DOI：
10.1038/nrc2931
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发表时间：
2010-10
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癌症可以在我们的DNA水平上被控制，这一发现为设计逆转肿瘤细胞表观遗传状态的疗法带来了一个新纪元。了解染色质动力学改变是如何导致恶性肿瘤的，对于控制肿瘤细胞而不影响正常细胞至关重要。多梳蛋白和三胸蛋白在进化上是保守的，并将染色质维持在“关”或“开”状态，从而分别阻止或促进基因表达。最近的工作强调了这些相反类别的蛋白质之间的动态相互作用，为理解这些表观遗传调节因子如何在肿瘤发生中发挥作用提供了新的途径。
The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumor cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumor cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the “off” or “on” state, thereby preventing or promoting gene expression, respectively. Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis.