FMRI reveals a dissociation between grasping and perceiving the size of real 3D objects.
FMRI reveals a dissociation between grasping and perceiving the size of real 3D objects.
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fMRI揭示了抓握和感知实际3D对象的大小之间的解离。
DOI：
10.1371/journal.pone.0000424
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发表时间：
2007-05-09
期刊：
影响因子：
3.7
通讯作者：
Culham, Jody C.
中科院分区：
文献类型：
--
作者：
Cavina-Pratesi, Cristiana;Goodale, Melvyn A.;Culham, Jody C.
近15年来，其制定后，在人类大脑皮层的背侧动作流和腹侧感知流之间的神经功能分离的证据仍然主要是基于神经心理学的案例研究。到目前为止，没有明确的证据表明，在神经系统完好的人脑中，目标导向的行动与感知任务的表现对象特征的单独视觉计算。我们使用功能性磁共振成像来明确测试介导抓握尺寸计算的脑区是否与介导感知尺寸计算的脑区不同。受试者被呈现相同的真实的可抓握的3D物体，并被要求执行一些不同的任务：抓握，达到，大小歧视，模式歧视或被动观看。与之前的研究一样，背侧流中的前顶内区（AIP）在抓握过程中（当物体大小与抓握计划相关时）比在伸手过程中（当物体属性与运动计划无关时（抓握>伸手））更活跃。活动AIP没有调制，但是，当大小计算的背景下，一个纯粹的感知任务（大小=模式歧视）。 相反，腹侧流中的外侧枕叶（LO）皮质在计算感知（大小>模式辨别）而不是行动（抓握=达到）的大小时受到调制。 虽然在背侧和腹侧流的地区响应简单的介绍3D对象（被动观看），这些地区的差异激活取决于任务是否掌握或知觉歧视，分别。在同一个健康的大脑中，对一个物体进行双重编码的证明，一方面是为了动作，另一方面是为了感知，这为当前关于发生在背侧流和腹侧流中的神经编码的性质的辩论提供了实质性的贡献。
Almost 15 years after its formulation, evidence for the neuro-functional dissociation between a dorsal action stream and a ventral perception stream in the human cerebral cortex is still based largely on neuropsychological case studies. To date, there is no unequivocal evidence for separate visual computations of object features for performance of goal-directed actions versus perceptual tasks in the neurologically intact human brain. We used functional magnetic resonance imaging to test explicitly whether or not brain areas mediating size computation for grasping are distinct from those mediating size computation for perception. Subjects were presented with the same real graspable 3D objects and were required to perform a number of different tasks: grasping, reaching, size discrimination, pattern discrimination or passive viewing. As in prior studies, the anterior intraparietal area (AIP) in the dorsal stream was more active during grasping, when object size was relevant for planning the grasp, than during reaching, when object properties were irrelevant for movement planning (grasping>reaching). Activity in AIP showed no modulation, however, when size was computed in the context of a purely perceptual task (size = pattern discrimination). Conversely, the lateral occipital (LO) cortex in the ventral stream was modulated when size was computed for perception (size>pattern discrimination) but not for action (grasping = reaching). While areas in both the dorsal and ventral streams responded to the simple presentation of 3D objects (passive viewing), these areas were differentially activated depending on whether the task was grasping or perceptual discrimination, respectively. The demonstration of dual coding of an object for the purposes of action on the one hand and perception on the other in the same healthy brains offers a substantial contribution to the current debate about the nature of the neural coding that takes place in the dorsal and ventral streams.
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影响因子：
2
作者：
Connolly, JD;Andersen, RA;Goodale, MA
通讯作者：
Goodale, MA
DOI：
10.1016/j.cogbrainres.2004.10.006
发表时间：
2005-03-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Creem-Regehr, SH;Lee, JN
通讯作者：
Lee, JN
影响因子：
3.4
作者：
Faillenot, I;Sunaert, S;Orban, GA
通讯作者：
Orban, GA
影响因子：
2
作者：
Galletti, C;Kutz, DF;Fattori, P
通讯作者：
Fattori, P
影响因子：
2.7
作者：
Gardner, EP;Debowy, DJ;Babu, KS
通讯作者：
Babu, KS