Stochastic processes during mouse blastocyst patterning
Stochastic processes during mouse blastocyst patterning
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DOI：
10.1159/000118783
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Hiiragi, Takashi
中科院分区：
文献类型：
--
作者：
Dietrich, Jens Erik;Hiiragi, Takashi
哺乳动物着床前发育形成囊胚，这种结构能够植入母亲的子宫，以支持胚胎的进一步发育。在胚胎发育过程中，第一次分化事件将上皮性滋养外胚层与由原始内胚层和胚胎发生外胚层组成的内细胞群分开。虽然囊胚的形成过程看似简单，但其形态发生和谱系分化的机制尚不完全清楚。在这里，我们讨论的研究结果表明，随机过程的参与和外部线索的影响，在小鼠植入前发育的模式过程。版权所有(c) 2008 S. Karger AG，巴塞尔。
Mammalian preimplantation development serves to form a blastocyst, a structure that is able to implant into the mother's uterus to support further development of the embryo proper. In the developing conceptus, the first differentiation events separate the epithelial trophectoderm from the inner cell mass, which is comprised of the primitive endoderm and embryo-generating epiblast. Although the process of blastocyst formation may appear simple, its morphogenesis and the mechanism(s) of lineage specification are not yet fully understood. Here we discuss findings that suggest the involvement of stochastic processes and the influence of external cues in the patterning process during mouse preimplantation development. Copyright (c) 2008 S. Karger AG, Basel.