Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines
Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines
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DOI：
10.1007/s11130-009-0138-8
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发表时间：
2009-12-01
影响因子：
4
通讯作者：
Gorinstein, Shela
中科院分区：
文献类型：
--
作者：
Heo, Buk-Gu;Chon, Sang-Uk;Gorinstein, Shela
研究了24种朝鲜野菜的抗增殖活性。采用甲醇提取物对肺癌、乳腺癌、结肠癌和胃癌细胞的杀伤作用进行MTT法测定。结果表明，当提取物浓度为400 mg / l（-1）时，14株植物对肺癌细胞、6株中1株对乳腺癌细胞、6株中2株对结肠癌细胞的增殖活性分别达到80%以上。在不同浓度下，18种野菜对胃癌细胞的增殖抑制活性均在23.6%以上，但在600 mg（-1）浓度下，只有6种野菜对胃癌细胞的增殖抑制活性在80%以上。结果表明，400 mg / l（-1）浓度下，对肺癌细胞增殖的抑制作用超过95%，对当归（肺癌细胞和结肠癌细胞）增殖的抑制作用超过95%。综上所述，所研究的野生蔬菜甲醇提取物具有剂量依赖性的抗肿瘤活性，主要是其生物活性成分，主要是多酚类物质，但其中一些活性成分如细辛金丝桃对肺癌无效，甚至产生危害。
This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT assay. It was found that at the extract concentration of 400 mgL(-1) 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six-against breast cancer cells, and two plants among six-against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the antiproliferative activity over 80% in 600 mgL(-1). It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL(-1) inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas-both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables' methanol extracts possess dose dependent antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm.