Plasma glucose and the action of calorie restriction on aging
Plasma glucose and the action of calorie restriction on aging
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DOI：
10.1093/gerona/62.10.1059
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Strong, Randy
中科院分区：
文献类型：
--
作者：
McCarter, Roger;Mejia, Walter;Strong, Randy
我们检验了这样一个假设，即通过限制热量来延缓衰老的部分原因是在整个生命周期内血糖水平降低。将表达人GLUT 4小基因的雄性C57 BL/6小鼠（转基因[TG]小鼠）及其非转基因同窝小鼠（NTG小鼠）维持在无特定病原体的条件下。从6周龄开始，小鼠自由进食（A小鼠）或比自由进食（R小鼠）少40%。在整个生命周期中，存在三种不同的血糖水平，NTGA小鼠具有最高的每日水平，TGR小鼠具有最低的每日值，TGA和NTGR小鼠具有介于这些值之间的相似水平。尽管血浆葡萄糖存在差异，但在寿命（50%和10%存活率）、生理学和组织病理学方面测量的差异与饮食相关，而与血浆葡萄糖水平无关。我们的结论是，降低血糖的寿命是不是一个重要的因素，在行动的热量限制对老化过程。
We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50% and 10% survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.