Is low b-factors-based apparent diffusion coefficient helpful in assessing renal dysfunction?
Is low b-factors-based apparent diffusion coefficient helpful in assessing renal dysfunction?
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基于 b 因子的低表观扩散系数有助于评估肾功能障碍吗？
DOI：
10.1007/s11547-015-0577-2
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发表时间：
2016-01-01
影响因子：
8.9
通讯作者：
Xing, Wei
中科院分区：
文献类型：
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作者：
Ding, Jiule;Chen, Jie;Xing, Wei
为了探讨基于b因子的表观弥散系数（ADC）是否有助于评估肾功能不全，招募了44名受试者，并根据估计肾小球滤过率（eGFR）= 30 ml/min/1.73 m2的阈值将其分为重度肾损伤组（sRI）和非sRI组（non-sRI）。使用7个b因子（0、20、40、80、200、400和800 s/mm（2））进行自由呼吸DWI。在选择覆盖右肾最大部分的解剖切片后，感兴趣区域覆盖肾实质。对于每例受试者，通过将不同b因子下的信号强度分别拟合为单指数衰减，计算基于所有b因子小于400 s/mm（2）（ADC（0-400））和800 s/mm（2）（ADC（0-800））的两个表观扩散系数。结果发现，去除b因子（800 s/mm（2））后，自由呼吸DWI序列的检查时间可从3.27 min缩短至2.55 min，各组ADC值（0-400）均大于ADC值（0-800）（P < 0.05）。sRI组ADC（0-400）和ADC（0-800）均小于非sRI组（P < 0.01），且与eGFR呈线性相关（P < 0.05）。虽然在区分sRI和非sRI参与者的两个系数之间没有发现显著差异（P > 0.05），但ADC（0-400）和ADC（0-800）之间存在强相关性（r = 0.856，P < 0.001）。基于低b因子的ADC是减少检查时间而不牺牲其诊断性能的经济选择。
To investigate whether low b-factors-based apparent diffusion coefficient (ADC) is helpful in assessing renal dysfunction.Forty-four subjects were recruited, and classified as having severe renal injury group (sRI) or not (non-sRI) according to a threshold of estimated glomerular filtration rate (eGFR) = 30 ml/min/1.73 m(2). A free-breathing DWI with 7 b-factors (0, 20, 40, 80, 200, 400, and 800 s/mm(2)) was performed. After choosing an anatomical section that covered the largest part of right kidney, the regions of interest covered the renal parenchyma. For each subject, two apparent diffusion coefficients based on all b-factors less than 400 s/mm(2) (ADC(0-400)) and 800 s/mm(2) (ADC(0-800)) were calculated by fitting the signal intensity at different b-factors to a mono-exponential decay, respectively. It was found that the examination time of the free-breathing DWI sequence in this study can be reduced from 3.27 to 2.55 min if the b-factor (800 s/mm(2)) is removed.ADC(0-400) was larger than ADC(0-800) in each group (P < 0.05). Both ADC(0-400) and ADC(0-800) were smaller in the sRI group than those in the non-sRI group (P < 0.01), and they were linearly related with eGFR (P < 0.05). While a significant difference was not found between the two coefficients to differentiate sRI from non-sRI participants (P > 0.05), a strong correlation was present between ADC(0-400) and ADC(0-800) (r = 0.856, P < 0.001).The low b-factors-based ADC was an economical option for reducing the examination time without sacrificing its diagnostic performance.