Meta-analysis of Brazilian genetic admixture and comparison with other Latin America countries
Meta-analysis of Brazilian genetic admixture and comparison with other Latin America countries
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DOI：
10.1002/ajhb.22714
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Cavalcanti Brandao, Lucas Andre
中科院分区：
文献类型：
--
作者：
De Moura, Ronald Rodrigues;Campos Coelho, Antonio Victor;Cavalcanti Brandao, Lucas Andre
ObjectivesThis study aims at performing a systematic review and meta analysis with the studies of genetic mixture inference of Brazilian population and to comparison these results with the genetic mixture levels in other Latin American countries.MethodsWe searched for articles about the estimation of Brazilian genetic mixture published between 1980 and 2014 that used autosomal marker.然后，在全国和地区层面进行了荟萃分析。最后，我们比较了巴西的结果与其他估计从其他南部，中部和北美countries.ResultsWe分析了25项研究中的数据，在38个不同的巴西人群。欧洲（EUR）血统是巴西人遗传背景的主要贡献者，其次是非洲（AFR）和美洲印第安人（AMR）血统。合并的祖先贡献为0.62欧元，0.21 AFR和0.17 AMR。南部地区的欧元贡献（0.77）高于其他地区。东北地区个体的AFR贡献最大（0.27），而北部地区个体的AMR贡献最大（0.32）。在拉丁美洲的背景下，巴西有5个高欧元的贡献，第12次的AFR组件和第10次的AMR ancestry.ConclusionsAdmixture比例变化很大，巴西人口之间，也通过拉丁美洲。需要在中西部、北部和东北部地区进行更多的研究，以更全面地了解巴西的基因组祖先。Am. J.哈姆。27：674-680，2015. (c)2015 Wiley Periodicals，Inc.
ObjectivesThis study aims at performing a systematic review and meta-analysis with the studies of genetic admixture inference of Brazilian population and to compare these results with the genetic admixture levels in other Latin American countries.MethodsWe searched for articles regarding the estimation of Brazilian genetic admixture published between 1980 and 2014 that used autosomal markers. Then, conducted meta-analyses at the whole-country and regional level. Finally, we compared the results of Brazil with other estimates from other South, Central and North American countries.ResultsWe analyzed data from 25 studies in 38 different Brazilian populations. European (EUR) ancestry is the major contributor to the genetic background of Brazilians, followed by African (AFR), and Amerindian (AMR) ancestries. The pooled ancestry contributions were 0.62 EUR, 0.21 AFR, and 0.17AMR. The Southern region had a greater EUR contribution (0.77) than other regions. Individuals from the Northeast (NE) region had the highest AFR contribution (0.27) whereas individuals from the North regions had more AMR contribution (0.32). In the Latin America context, Brazil has the 5th high EUR contribution, the 12th for the AFR component and the 10th for the AMR ancestry.ConclusionsAdmixture proportions vary greatly among Brazilian populations and also through Latin America. More studies in the Center-West, North and NE regions are needed to capture a more complete picture of the genomic ancestry of Brazil. Am. J. Hum. Biol. 27:674-680, 2015. (c) 2015 Wiley Periodicals, Inc.