Spatial and temporal circulation of dengue virus serotypes: A prospective study of primary school children in Kamphaeng Phet, Thailand
Spatial and temporal circulation of dengue virus serotypes: A prospective study of primary school children in Kamphaeng Phet, Thailand
复制标题
DOI：
10.1093/aje/kwf006
复制
发表时间：
2002-07-01
影响因子：
5
通讯作者：
Ennis, FA
中科院分区：
文献类型：
--
作者：
Endy, TP;Nisalak, A;Ennis, FA
登革热病毒有四种不同的血清型，每种血清型都会在世界热带和亚热带地区引起流行。很少有研究研究多种登革热病毒血清型在明确的队列人群中随时间的共同循环及其产生严重登革热疾病的能力。在本文中，作者报告了一项正在进行的前瞻性研究的前 3 年（1998-2000 年）的细节和结果，该研究针对泰国北部一组儿童中的登革热病毒传播和疾病严重程度。从167例急性登革热病毒感染中获得了108株登革热病毒分离株； 23% 为 DEN-1，35% 为 DEN-2，41% 为 DEN-3，1% 为 DEN-4。尽管学校距离很近，但每种登革热血清型的传播在空间和时间上都存在明显的聚集性。登革热传播季节之前的血清型特异性抗体水平并不能预测登革热病毒感染的发生率或个别学校传播的主要血清型。尽管 DEN-3 比其他登革热血清型产生更严重的症状，但所有登革热血清型都会产生严重的登革热疾病。作者的研究结果强调了登革热血清型特异性病毒传播和严重登革热疾病的复杂性，并对登革热控制和疫苗开发具有重要意义。
Dengue virus occurs as four distinct serotypes, each of which causes epidemics throughout the tropical and subtropical regions of the world. Few studies have examined co-circulation of multiple dengue virus serotypes in a well-defined cohort population over time and their capacity to produce severe dengue disease. In this paper, the authors report the details and findings of the first 3 years (1998-2000) of an ongoing prospective study of dengue virus transmission and disease severity in a cohort of children in northern Thailand. A total of 108 dengue virus isolates were obtained from 167 acute dengue virus infections; 23% were DEN-1, 35% were DEN-2, 41% were DEN-3, and 1% were DEN-4. Despite the proximity of the schools, there was marked spatial and temporal clustering of transmission of each dengue serotype. Serotype-specific antibody levels prior to the dengue transmission season were not predictive of the incidence of dengue virus infections or the predominant serotype transmitted at individual schools. All dengue serotypes produced severe dengue illness, although DEN-3 produced more severe symptoms than the other dengue serotypes. The authors' findings emphasize the complexity of dengue serotype-specific virus transmission and severe dengue disease and have important implications for dengue control and vaccine development.