Effect of leaking perifoveal microaneurysms on resolution of diabetic macular edema treated by combination therapy using anti-vascular endothelial growth factor and short pulse focal/grid laser photocoagulation
Effect of leaking perifoveal microaneurysms on resolution of diabetic macular edema treated by combination therapy using anti-vascular endothelial growth factor and short pulse focal/grid laser photocoagulation
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DOI：
10.1007/s10384-016-0483-8
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发表时间：
2017-01-01
影响因子：
2.4
通讯作者：
Murata, Toshinori
中科院分区：
文献类型：
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作者：
Hirano, Takao;Toriyama, Yuichi;Murata, Toshinori
评价玻璃体内注射雷珠单抗（IVR）和短脉冲局灶/格栅激光光凝联合治疗糖尿病性黄斑水肿（DME）的效果。目前的研究是一项在日本4个研究中心对21只眼进行的初步单臂、开放标签、前瞻性临床研究。治疗方案包括两个阶段。诱导IVR阶段包括两个月一次的IVR，随后是PRN IVR阶段，如果中心黄斑厚度（CMT）超过300 μ m，则进行额外的IVR。在两个阶段的每次IVR后一周，输送短脉冲局灶/网格激光以治疗中央凹外的残余渗漏（> 500 μ m）并减少水肿液流入。在6个月的终点，根据最佳矫正视力（BCVA）、CMT和有或无中心凹周围渗漏微动脉瘤（MA）的眼睛中所需的IVR注射次数检查治疗效果。
The effect of combination therapy using intravitreal ranibizumab (IVR) injections and short pulse focal/grid laser photocoagulation was evaluated for the treatment of diabetic macular edema (DME).The current investigation was a preliminary single-arm, open-label, prospective clinical study conducted on 21 eyes at 4 sites in Japan. Treatment protocol consisted of two phases. The induction IVR phase included two monthly IVRs followed by PRN IVR phase in which additional IVR was administered if the central macular thickness (CMT) exceeded 300 mu m. One week after each IVR in both phases, short pulse focal/grid laser was delivered to treat residual leakage outside of the fovea (> 500 mu m) and reduce edema fluid influx. At the 6-month endpoint, the effects of treatment were examined in terms of best corrected visual acuity (BCVA), CMT, and required number of IVR injections in eyes with or without perifoveal leaking microaneurysms (MAs).In eyes with initial BCVA