Gargling with sodium azulene sulfonate reduces the postoperative sore throat after intubation of the trachea
Gargling with sodium azulene sulfonate reduces the postoperative sore throat after intubation of the trachea
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DOI：
10.1213/01.ane.0000156565.60082.7c
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发表时间：
2005-07-01
影响因子：
5.7
通讯作者：
Sata, T
中科院分区：
文献类型：
--
作者：
Ogata, J;Minami, K;Sata, T
术后咽喉痛（POST）是接受气管插管患者的一种尚待解决的并发症。在这项研究中，我们研究了术前用1，4-二甲基-7-异丙基甘菊环-3-磺酸钠一水合物（甘菊环磺酸钠，Azunol）漱口是否会减少气管插管后的POST。将40例择期全麻手术患者随机分为Azunol组和对照组。Azunol组患者用4 mg Azunol用100 mL自来水稀释（40 μ g/mL）漱口。对照组用100 mL自来水漱口。从全身麻醉中苏醒后，对出现POST的患者进行计数，并使用口头模拟疼痛量表对POST进行评价。两组之间的年龄、身高、体重、性别分布或麻醉和手术持续时间无显著差异。在对照组中，13名患者（65%）抱怨POST，其中9名患者（45%）在24小时后仍然存在。在Azunol组中，5名患者（25%）还抱怨POST，24小时后完全消失。与对照组相比，Azunol组的POST和言语模拟疼痛量表评分的发生率显著降低。我们证明了用Azunol漱口可以有效地减轻POST而没有不良反应。
Postoperative sore throat (POST) is a complication that remains to be resolved in patients undergoing endotracheal intubation. In this study, we investigated whether preoperative gargling with sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate monohydrate (sodium azulene sulfonate, Azunol) reduces POST after endotracheal intubation. Forty patients scheduled for elective surgery under general anesthesia were randomized into Azunol and control groups. In the Azunol group, patients gargled with 4 mg Azunol diluted with 100 mL tap water (40 mu g/mL). In the control group, patients gargled with 100 mL of tap water. After emergence from general anesthesia, the patients with POST were counted and POST was evaluated using a verbal analog pain scale. There were no significant differences between the two groups by age, height, body weight, gender distribution, or duration of anesthesia and surgery. In the control group, 13 patients (65%) complained of POST, which remained 24 h later in nine patients (45%). In the Azunol group, five patients (25%) also complained of POST, which completely disappeared by 24 h later. The incidence of POST and verbal analog pain scale scores in the Azunol group decreased significantly compared with the control group. We demonstrated that gargling with Azunol effectively attenuated POST with no adverse reactions.