Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 2. Tetrapeptide and decapeptide analogues.
Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 2. Tetrapeptide and decapeptide analogues.
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黄体生成素释放激素分子的构象能分析。
DOI：
10.1021/ja00426a053
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发表时间：
1976
影响因子：
15
通讯作者：
F. Momany
中科院分区：
文献类型：
--
作者：
F. Momany
使用“经验”能量计算获得了促黄体激素释放激素（<Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2）的低能构象。将<Glu * 至Gly6和Gly6至Gly10-NH2的部分的构象空间作为单独的实体进行搜索，然后将这两个部分的最小能量构象用作用于完善完整分子的起始构象。最小能量结构与一系列氨基酸取代类似物的实验测定数据一致。
Low-energy conformations of luteinizing hormone-releasing hormone (< Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) have been obtained using “empirical” energy calculations. The conformational space of the sections< Glu* to Gly6 and Gly6 to Gly10-NH2 was searched as separate entities, and the minimum energy conformations of these two sections were then used as starting conformations for refinement of the complete molecule. The minimum energy structure is consistent with experimental assay dataderived from a series of amino acid substitution analogues.