Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists.
Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists.
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DOI：
10.1097/00043764-199706000-00013
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发表时间：
1997-06
影响因子：
3.2
通讯作者：
B. Valanis;W. Vollmer;K. Labuhn;A. Glass
中科院分区：
文献类型：
--
作者：
B. Valanis;W. Vollmer;K. Labuhn;A. Glass
尽管不孕症已被确定为某些癌症患者化疗的影响，但不孕症与职业暴露的关系尚未得到研究。这项病例对照研究调查了不孕症与护士和药房人员职业处理化疗药物的关系。数据通过参与国家癌症研究所国家外科辅助乳腺和肠道项目协作临床试验网络的机构的 4659 名工作人员进行问卷调查收集。 405 名报告不孕不育的受试者均按性别和年龄与三名对照受试者进行匹配，并比较化疗药物处理史。总样本和女性的结果显示，自我报告的不孕症与不孕症发作前职业性处理化疗药物相关的比值比显着升高（OR = 1.5；CI = 1.1 至 2.0）。对于男性来说，优势比相似，但没有统计学意义。这群工人的平均年龄为37岁，正处于生育高峰期。通过使用现有的保护措施来预防化疗副作用比冒着不孕的风险要好。
Although infertility has been identified as an effect of chemotherapy for some cancer patients, the association of infertility with occupational exposure has not been investigated. This case-control study investigated the relationship of infertility with occupational handling of chemotherapy drugs by nurses and pharmacy personnel. Data were gathered by questionnaire from 4659 staff at facilities participating in the National Surgical Adjuvant Breast and Bowel Project collaborative clinical trials network of the National Cancer Institute. The 405 subjects reporting infertility were each matched by sex and age with three control subjects and compared for history of chemotherapeutic drug handling. Results for the total sample and for women showed a significantly elevated odds ratio (OR = 1.5; CI = 1.1 to 2.0) for self-reported infertility associated with occupational handling of chemotherapeutic drugs prior to onset of infertility. For men, the odds ratio was similar but not statistically significant. This worker population, with a mean age of 37, is in the prime of reproductive life. Prevention of chemotherapy side effects by use of available protection is preferable to risking infertility.