Factors influencing the antibody response of dogs vaccinated against rabies
Factors influencing the antibody response of dogs vaccinated against rabies
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DOI：
10.1016/j.vaccine.2007.10.015
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发表时间：
2007-12-12
期刊：
影响因子：
5.5
通讯作者：
Ollier, William E. R.
中科院分区：
文献类型：
--
作者：
Kennedy, Lorna J.;Lunt, Mark;Ollier, William E. R.
自2000年以来，英国有一项法律的要求，如果狗和猫的主人希望避免在重新进入英国时被隔离，则狗和猫应该进行有效的狂犬病疫苗接种，并证明血清转化。2002年，在VLA对10 483只狗进行了狂犬病滴度测定。统计分析评估了每种疫苗在不同犬种中的有效性。动物大小、年龄、品种、采样时间和疫苗对合格率和中位滴度有显著影响。我们的数据表明，动物的大小和抗体反应水平之间存在一般的关系，较小的狗引起较高的抗体水平比较大品种的狗。然而，不同品种犬之间的差异不仅在于接种疫苗后立即产生的应答强度，还在于免疫持续时间。另一项观察结果是，小于1岁的幼龄动物对狂犬病疫苗接种产生的抗体应答低于成年动物。对于测试的不同疫苗，也观察到相当高的失败率。回归分析显示，两种疫苗表现同样好，并且明显优于其他测试疫苗。与接种后采样间隔时间相关的抗体应答变化并非意外，推测与初次接种的应答动力学相关。这些数据需要正确看待，以尽量减少狂犬病再次传入无狂犬病国家的风险，特别是在考虑取消对参加宠物旅行计划的狂犬病疫苗接种犬只进行血清学测试的要求时。(c)2007爱思唯尔有限公司保留所有权利。
Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the efficacy of each vaccine within different dog breeds. Animal size, age, breed, sampling time and vaccine had significant effects on pass rates and median titres. Our data suggests that a general relationship between animal size and level of antibody response exists and smaller sized dogs elicited higher antibody levels than larger breeds of dog. It was not however, only the magnitude of response immediately following vaccination but also the duration of immunity that varied between breeds of dog. Another observation was that young animals, less than 1-year of age, generated a lower antibody response to rabies vaccination than adults. Considerably higher failure rates were also observed for different vaccines tested. Regression analysis revealed that two vaccines performed equally well, and significantly better than the others tested. The variation in antibody response relating to length of interval of sampling following vaccination is not unexpected and presumably relates to the response kinetics for primary vaccination. These data need to be placed in perspective in order to minimise the risk of rabies being re-introduced into a rabies-free country, especially in the consideration of removing the requirement for serological testing for rabies vaccinated dogs that participate in pet travel schemes. (c) 2007 Elsevier Ltd. All rights reserved.