Charles David Allis (1951-2023).
Charles David Allis (1951-2023).
复制标题
查尔斯·大卫·艾利斯（1951-2023）。
DOI：
10.1038/s41588-023-01331-z
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发表时间：
2023
期刊：
影响因子：
30.8
通讯作者：
Wang,GangGreg
中科院分区：
文献类型：
--
作者：
Chi,Ping;Lewis,PeterW;Lu,Chao;Lu,Janice;Ruthenburg,AlexanderJ;Sabari,BenjaminR;Shechter,David;Wan,Liling;Wang,GangGreg
Charles David Allis, a world-renowned leader in the field of chromatin biology, passed away on 8 January 2023, at the age of 71. Like many, we were deeply shocked, devastated and heartbroken. We take comfort in knowing that Dave spent the last few days surrounded by family. We remember and celebrate Dave for his enormous impact on biomedical science, for his inspiring mentorship, magnanimous collaboration and genuine friendship, and for being an overall wonderful person.Dave was born and raised in Cincinnati, Ohio. He earned a bachelor’s degree from the University of Cincinnati in 1973 and a PhD in developmental biology from the Mahowald lab at Indiana University in 1978. Starting with postdoctoral research in the Gorovsky lab at the University of Rochester, Dave dedicated the rest of his career to pioneering research in chromatin biology, in which he made numerous groundbreaking discoveries that profoundly shaped the field. In many ways, Dave was ahead of his time. On the basis of his earlier work with the ciliate Tetrahymena, Dave recognized that histones had roles beyond being the inert spools around which nuclear DNA winds. In 1996, Dave and James Brownell, a graduate student in his lab, published a landmark paper that identified the first histone acetyltransferase as a homolog of the yeast transcriptional co-activator Gcn5 (ref. 1). This discovery, together with previous genetic studies (especially those from the lab of Michael Grunstein at the University of California, Los Angeles), revolutionized the chromatin field by unambiguously linking specific chemical modifications of histone proteins to transcriptional regulation. These discoveries launched exponential growth in understanding how chromatin regulates the genome. With the Allis lab having a leading role, this research had far-ranging effects on our fundamental understanding of human health and disease.
