Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes
Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes
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DOI：
10.1007/s10965-013-0166-9
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发表时间：
2013-05
影响因子：
2.8
通讯作者：
Y. Nien;C. Shih;Chih-Yuan Yang;Chien‐Ju Lu;Quan-Xun Ye
中科院分区：
文献类型：
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作者：
Y. Nien;C. Shih;Chih-Yuan Yang;Chien‐Ju Lu;Quan-Xun Ye
在这项研究中，我们制备了通过静电纺丝制造的静电纺丝聚己内酯/聚环氧乙烷（PCL/PEO）膜。我们设计了用于医疗贴片应用的膜。为了了解膜用于医疗贴剂时的药物释放行为，使用酮洛芬作为模型药物。结果表明，包含 PCL/PEO 的负载酮洛芬的电纺膜在 30 分钟内释放出所有酮洛芬。该膜在医疗贴片中具有潜在的应用前景。此外，PCL/PEO溶液的粘度随着PEO比例的增加而增加。所有 PCL/PEO 溶液的低电导率是由于 PCL 和 PEO 分子上缺乏电荷造成的。较高的 PEO 百分比与电纺 PCL/PEO 膜的高熔化热相关。 PCL/PEO复合材料中PEO的结晶度随着PEO含量的降低而降低。
In this study, we prepared electrospun polycaprolactone/polyethylene oxide (PCL/PEO) membranes fabricated by electrospinning. We designed the membranes for the application of medical patch. In order to understand the drug-released behavior when the membranes were used in medical patch, ketoprofen was used as a model drug. The results show that ketoprofen-loaded electrospun membranes that comprised PCL/PEO released all ketoprofen in 30 min. The mebranes had potential application in medical patch. In additions, the viscosity of the PCL/PEO solution increased with the proportion of PEO. The low conductivities of the all PCL/PEO solutions were caused by the lack of electric charge on both PCL and PEO molecules. A higher PEO percentage was associated with high enthalpy of fusion of the electrospun PCL/PEO membrane. The crystallinity of PEO in the PCL/PEO composite decreased as the PEO content declined.