NEURAL GENERATORS OF EARLY CORTICAL SOMATOSENSORY-EVOKED POTENTIALS IN THE AWAKE MONKEY
NEURAL GENERATORS OF EARLY CORTICAL SOMATOSENSORY-EVOKED POTENTIALS IN THE AWAKE MONKEY
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DOI：
10.1016/0168-5597(95)00006-e
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发表时间：
1995-05-01
期刊：
影响因子：
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通讯作者：
AREZZO, JC
中科院分区：
文献类型：
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作者：
PETERSON, NN;SCHROEDER, CE;AREZZO, JC
关于体感诱发电位 (SEP) 的初始皮质成分的生成器仍然存在争议。通过对旧大陆猴子的体感诱发活动进行详细的硬膜外和皮质内绘图来探讨这个问题。在深度记录中，使用了 3 个补充程序：（1）从大约 4000 个位置确定 SEP 的皮质内和皮质下分布； (2) 记录多单位活动 (MUA) 的伴随概况，作为局部动作潜力概况的估计； (3)使用电流源密度(CSD)的一维计算来概述区域跨膜电流的时间和模式。我们的分析证实了位于中央沟两侧的多个皮质区域参与了初始皮质 SEP 成分的生成。最早的活动 P10 位于区域 3，随后在几毫秒内激活区域 1、2 (P12) 和 4 (P13)。在 SI（布罗德曼区 3、1 和 2）中，最初的 SEP 成分反映了第 4 层星状细胞的去极化以及随后第 3 层和第 5 层中相邻锥体细胞的激活。后来皮质成分（P20、N45）的起源代表了分布在多个皮质层上的活动的复合体以及重叠的兴奋性和抑制性事件的相互作用。这些发现对 SEP 波形的临床解释有直接影响。
Controversy continues to exist regarding the generators of the initial cortical components of the somatosensory evoked potential (SEP). This issue was explored by detailed epidural and intracortical mapping of somatosensory evoked activity in Old World monkeys. In depth recordings, 3 complementary procedures were utilized: (1) the intracortical and subcortical distribution of SEPs was determined from approximately 4000 locations; (2) concomitant profiles of multiple unit activity (MUA) were recorded as an estimate of local action potential profiles; (3) 1-dimensional calculations of current source density (CSD) were used to outline the timing and pattern of regional transmembrane current flow. Our analysis confirms the participation of multiple cortical areas, located on either side of the central sulcus, in the generation of the initial cortical SEP components. Earliest activity, P10, was localized to area 3, followed within milliseconds by activation of areas 1, 2 (P12), and 4 (P13). In SI (Brodmann's areas 3, 1 and 2), the initial SEP components reflect the depolarization of lamina 4 stellate cells and the subsequent activation of adjacent pyramidal cells in laminae 3 and 5. The genesis of later cortical components (P20, N45) represents the composite of activity distributed across multiple cortical laminae and the interaction of overlapping excitatory and inhibitory events. These findings have direct implications for the clinical interpretation of SEP waveforms.