LOCAL SUPPLY ENERGY TO FAST AXOPLASMIC TRANSPORT MECHANISM (CAT/IN-VITRO)
LOCAL SUPPLY ENERGY TO FAST AXOPLASMIC TRANSPORT MECHANISM (CAT/IN-VITRO)
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DOI：
10.1073/pnas.68.6.1279
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发表时间：
1971-01-01
影响因子：
11.1
通讯作者：
OCHS, S
中科院分区：
文献类型：
--
作者：
OCHS, S
猫坐骨神经小区域的局部缺氧会导致体外快速轴浆运输受阻。活性在缺氧区域的表面受到阻碍，并在缺氧区域内的远端迅速下降。如果这些块在 1 小时内被移除，则它们是可逆的。早期的研究已经证明，轴浆的快速运输密切依赖于氧化代谢产生的 ATP。目前的结果表明，沿着神经纤维的整个长度都需要 ATP 来提供假设的快速运输“运输丝”机制。
Local anoxia of a small region of cat sciatic nerves causes a block of fast axoplasmic transportin vitro. Activity becomes dammed up at the face of the anoxic region, and falls off rapidly distally just inside the anoxic region. Such blocks were reversible if they were removed within 1 hr. Earlier studies had given evidence that fast axoplasmic transport is closely dependent on ATP derived from oxidative metabolism. The present results indicate that ATP is required all along the length of the nerve fiber to supply a hypothesized “transporting filament” mechanism of fast transport.