Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris
Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris
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DOI：
10.1016/s0092-8674(03)00273-3
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发表时间：
2003-04-18
期刊：
影响因子：
64.5
通讯作者：
Christiano, AM
中科院分区：
文献类型：
--
作者：
Kljuic, A;Bazzi, H;Christiano, AM
细胞粘附和通讯是细胞行为的相互依赖方面，对形态发生和组织结构至关重要。在皮肤中，表皮粘附部分是由称为桥粒的特化细胞-细胞连接介导的，其特征是桥粒体钙粘蛋白的存在，称为桥粒蛋白和桥粒素。我们发现了一个钙粘蛋白家族成员，粘蛋白4，它在基底上表皮和毛囊中表达。通过鉴定遗传性毛少症家族和披针形毛鼠的突变，确定了粘粒蛋白4在皮肤中的重要作用。我们还发现DSG4是寻常型天疱疮的自身抗原。自然发生的突变小鼠的表型特征揭示了桥粒粘连的破坏和角化细胞行为的扰动。我们提供的证据表明，桥蛋白4是毛囊中角质形成细胞粘附的关键介质，在那里它协调从增殖到分化的转变。
Cell adhesion and communication are interdependent aspects of cell behavior that are critical for morphogenesis and tissue architecture. In the skin, epidermal adhesion is mediated in part by specialized cell-cell junctions known as desmosomes, which are characterized by the presence of desmosomal cadherins, known as desmogleins and desmocollins. We identified a cadherin family member, desmoglein 4, which is expressed in the suprabasal epidermis and hair follicle. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. We also show that DSG4 is an autoantigen in pemphigus vulgaris. Characterization of the phenotype of naturally occurring mutant mice revealed disruption of desmosomal adhesion and perturbations in keratinocyte behavior. We provide evidence that desmoglein 4 is a key mediator of keratinocyte cell adhesion in the hair follicle, where it coordinates the transition from proliferation to differentiation.