Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients.
Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients.
复制标题
DOI：
10.1111/j.1600-6143.2011.03454.x
复制
发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Tsai de E
中科院分区：
文献类型：
--
作者：
Reshef R;Luskin MR;Kamoun M;Vardhanabhuti S;Tomaszewski JE;Stadtmauer EA;Porter DL;Heitjan DF;Tsai de E
在一项病例对照研究中，对110名患有PTLD的实体器官移植受者和5601名未患PTLD的实体器官移植受者进行了比较，研究了人类白细胞抗原多态与PTLD之间的关系。分析供者和受者的人类白细胞抗原。我们发现受体HLAA26与PTLD的发生显著相关(OR2.74；P=0.0007)。在高加索受者中，受者和供者的HLAA26与PTLD的发生独立相关(受者A26或供者A26或2.99；P=0.0004，供者A26或2.81；P=0.002)。HLAA、B单倍型分析显示，受者HLAA26、B38单倍型与EB病毒阳性PTLD的发生率显著相关(OR3.99；p=0.001)。供者携带的共同祖先单倍型HLA-A1、B8、DR3对PTLD有保护作用(OR 0.41；p=0.05)。其他几种人类白细胞抗原的特异性与临床和病理特征以及存活率有关。这些发现证明了人类白细胞抗原基因多态性在调节PTLD风险中的重要性，并可能有助于风险分层以及监测和预防策略的制定。
The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; P=0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; P=0.0004, donor A26 OR 2.81; P=0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p=0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p=0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.
登录
查看更多内容
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
突尼斯人中HLA I类等位基因与鼻咽癌（NPC）的患病率之间的关联。
影响因子：
7.4
作者：
Li X;Ghandri N;Piancatelli D;Adams S;Chen D;Robbins FM;Wang E;Monaco A;Selleri S;Bouaouina N;Stroncek D;Adorno D;Chouchane L;Marincola FM
通讯作者：
Marincola FM
DOI：
10.1073/pnas.071548198
发表时间：
2001-04-24
影响因子：
11.1
作者：
Flores-Villanueva, PO;Yunis, EJ;Goldfeld, AE
通讯作者：
Goldfeld, AE
影响因子：
6.5
作者：
Kamper, PM;Kjeldsen, E;d'Amore, F
通讯作者：
d'Amore, F
影响因子：
11.2
作者：
Madeleine, Margaret M.;Johnson, Lisa G.;Galloway, Denise A.
通讯作者：
Galloway, Denise A.