Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules.
Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules.
复制标题
咬合不和谐通过认知抑制分子暂时降低认知能力，并通过清除分子部分恢复认知能力。
DOI：
10.1016/j.bbrc.2022.01.048
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ohno J
中科院分区：
文献类型：
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作者：
Maeshiba M;Kajiya H;Tsutsumi T;Migita K;Goto-T K;Kono Y;Tsuzuki T;Ohno J
据报道，咬合不和谐不仅受周围器官细胞因子和类固醇激素分泌和交感神经激活的影响，还受中枢神经系统神经递质释放的影响。然而，对于咬合不和谐是否会降低认知能力，我们知之甚少。我们假设高闭塞症通过大脑中阿尔茨海默病相关分子表达降低认知能力。本研究旨在阐明咬合失调、脑内细胞因子和认知调节分子表达与学习记忆认知障碍的关系。我们使用高闭塞小鼠模型研究了高闭塞对细胞因子表达、海马认知抑制分子和行为认知之间关系的影响。2月龄小鼠高咬合负荷1周后，高咬合显著增加血清和海马中白细胞介素-1β的表达，但对12月龄小鼠无影响。2月龄小鼠的社交和长期认知能力在高闭塞1周后短暂下调至接近12月龄小鼠的水平，并通过认知抑制清除蛋白的表达恢复至接近基础水平。2月龄小鼠高咬合负荷1周后，海马中淀粉样蛋白-β和磷酸化tau蛋白的表达水平显著上调，而12月龄小鼠的表达水平不变。咬合不和谐诱导的白介素-1β表达可能有助于认知抑制分子（如淀粉样蛋白-β和磷酸化的tau）的积累，并激活它们的清除蛋白，从而防止年轻人而不是老年人的短暂性痴呆。
Occlusal disharmony has been reported to be affected not only by cytokine and steroid hormone secretion and sympathetic activation in peripheral organs, but also by neurotransmitter release in the central nervous system. However, little is known about whether occlusal disharmony can decrease cognitive ability. We hypothesized that hyperocclusion decreases cognition via Alzheimer's disease-associated molecule expression in the brain. The present study is aimed to elucidate the relationships among occlusal disharmony, cytokine and cognitive-regulated molecule expression in the brain, and the impairment of learning and memory cognition.We examined the effect of hyperocclusion on the relationships among cytokine expression, cognitive suppressor molecules in the hippocampus, and cognition in behavior using a hyperocclusion mouse model. Hyperocclusion dramatically increased interleukin-1β expression in the serum and hippocampus 1 week after hyperocclusal loading in 2-month-old mice, but no effects in 12-month-old mice. The social and long-term cognitive abilities of the 2-month-old mice were transiently downregulated close to the level of the 12-month-old mice 1 week after hyperocclusion and recovered to close to basal level via the expression of cognitive suppressor clearing proteins. The expression levels of amyloid-β and phosphorylated tau were significantly upregulated 1 week after hyperocclusal loading in the hippocampus of 2-month-old mice but were constant in 12-month-old mice. Occlusal disharmony-induced interleukin-1β expression may contribute to accumulation of cognitive suppressor molecules such as amyloid-β and phosphorylated tau and activate their clearance proteins, resulting in protection against transient dementia in young but not older individuals.