Epidemiologic associations between occupational and environmental exposures and autoimmune disease: report of a meeting to explore current evidence and identify research needs.
Epidemiologic associations between occupational and environmental exposures and autoimmune disease: report of a meeting to explore current evidence and identify research needs.
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职业和环境暴露与自身免疫性疾病之间的流行病学关联：探讨当前证据并确定研究需求的会议报告。
DOI：
10.1078/1438-4639-00057
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发表时间：
2001
影响因子：
6
通讯作者：
McMichael,AJ
中科院分区：
文献类型：
--
作者：
VanLoveren,H;Vos,JG;Germolec,D;Simeonova,PP;Eijkemanns,G;McMichael,AJ
为了加深对与环境因素相关的自身免疫的了解，2000年5月10日至12日在荷兰比尔托芬组织了一次“与自身免疫相关的职业和环境因素的流行病学探索性会议”。即使不能就某些化学物质在环境和工作场所中引起或加剧自身免疫反应和疾病的作用得出明确的结论，也有许多迹象表明这种情况会发生。会议的目的是确定评估人类群体中与职业或环境暴露相关的自身免疫的最佳方法，并建立跨学科和协作的流行病学研究，以调查暴露于二氧化硅、六氯苯、紫外线辐射和其他制剂与人类群体中自身免疫和自身免疫性疾病的关系。这些特工被选为目前特别可疑的特工。结论是，有必要在实验室动物中进行实验研究和临床调查，以提高对环境引起的自身免疫性疾病的原因和机制及其治疗的科学知识；此外，还需要对人类群体中这些疾病的环境和其他原因的流行病学研究采取跨学科的方法。审查了这方面的流行病学研究的具体设计，以及对健康结果的实验室分析。对用流行病学方法评估环境或职业制剂对自身免疫的影响提出了几点建议。主要建议如下：1)需要关于自身免疫和自身免疫疾病的系统描述性流行病学数据；2)应鼓励建立疾病报告登记处；3)应鼓励为所有自身免疫疾病制定国际公认的标准诊断标准；4)应评估这些疾病的社会影响，并估计直接和间接经济损失；5)应标准化流行病学研究中使用的暴露评估方法；6)应标准化衡量生物反应的实验室方法；7)应鼓励将自身免疫和自身免疫疾病以及相关环境暴露的指标纳入正在进行的流行病学研究。研究自身免疫性疾病和自身免疫的环境原因的重要性在于识别和预防对公共健康的风险，以及提高我们对健康和疾病的基本机制的认识。
To advance understanding of autoimmunity associated with exposure to environmental factors, an “Exploratory Meeting Epidemiology on Occupational and Environmental Factors Associated with Autoimmunity” was organized in Bilthoven, the Netherlands, from May 10-12, 2000. Even if no firm conclusions can be drawn on a role of certain chemicals in the environment and in the work place in causing or exacerbating autoimmune responses and illnesses, many indications of this to occur exist. The aim of the meeting was to determine the optimal methodology for assessment of autoimmunity associated with occupational or environmental exposures in the human population, and to set up interdisciplinary and collaborative epidemiological studies to investigate the association of exposure to silica, hexachlorobenzene, ultraviolet radiation, and other agents with autoimmunity and autoimmune diseases in the human population. These agents were selected as carrying particular suspicion at present. It was concluded that there is a need for experimental studies in laboratory animals and for clinical investigations to improve scientific knowledge about the causes and mechanisms of environmentally-induced autoimmune disorders and their treatment; in addition there is a need for an interdisciplinary approach to epidemiological studies of the environmental and other causes of these disorders in human populations. Specific designs for epidemiological studies in this context, as well as laboratory assays for health outcomes, were reviewed. Several recommendations for the epidemiological approach to evaluating effects of environmental or occupational agents on autoimmunity were made. The prime recommendations are the following: 1) systematic descriptive epidemiological data on autoimmunity and autoimmune disorders are required; 2) the establishment of disease-reporting registries should be encouraged; 3) the development of internationally accepted standard diagnostic criteria for all autoimmune diseases should be encouraged; 4) the social impact of these disorders should be evaluated and estimations of direct and indirect economic costs should also be made; 5) the methods of exposure assessment used in epidemiological studies should be standardized; 6) laboratory methods for measurement of biological responses should be standardized; and 7) the inclusion of indicators of autoimmunity and autoimmune diseases and of relevant environmental exposures in ongoing epidemiological studies should be encouraged. The importance of studying environmental causes of autoimmune diseases and autoimmunity lies in the identification and prevention of risks to the public health, and in improving our knowledge of basic mechanisms of health and disease.