Ph1-positive acute lymphocytic leukemia with chromosome 7 abnormalities.
Ph1-positive acute lymphocytic leukemia with chromosome 7 abnormalities.
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Ph1 阳性急性淋巴细胞白血病伴 7 号染色体异常。
DOI：
10.1182/blood.v49.2.281.bloodjournal492281
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发表时间：
1977
期刊：
影响因子：
20.3
通讯作者：
M. Djaldetti
中科院分区：
文献类型：
--
作者：
Mandel Em;F. Shabtai;U. Gafter;B. Klein;I. Halbrecht;M. Djaldetti
一位56岁女性急性淋巴细胞白血病患者在90%的骨髓中期细胞和10%的外周血中期细胞中发现了费城染色体。G22染色体长臂的一部分易位到C9染色体长臂。第二个细胞遗传学异常被发现在7号染色体。在60%的骨髓和20%的外周血中期细胞中发现了7号单体。染色体7 q-也被发现在一小部分的中期检查。三个月后，当患者部分缓解时，只有10%的骨髓细胞显示7号染色体单体和Ph 1染色体。在完全缓解期间，除了高断裂率外，未发现染色体异常。急性淋巴细胞白血病中Ph 1染色体的发现表明不同的前体细胞（粒细胞和淋巴细胞）可能参与了Ph 1过程。
A 56-yr-old woman with acute lymphocytic leukemia showed the presence of a Philadelphia chromosome in 90% of the bone marrow metaphases and in 10% of the peripheral blood metaphases. Part of the long arm of a G22 chromsome was translocated to the long arm of a C9 chromosome. A second cytogenetic abnormality was found in chromosome 7. Monosomy 7 was found in 60% of the marrow and in 20% of the peripheral blood metaphases. Chromosome 7q- was also found in a small percentage of the metaphases examined. Three months later, when the patient was in partial remission, only 10% of the marrow cells showed chromosome 7 monosomy and a Ph1 chromosome. During complete remission, no chromosomal abnormalities were found, except for a high breakage rate. The finding of a Ph1 chromosome in acute lymphocytic leukemia indicates that different precursors, both granulocytic and lymphocytic, may be involved in the Ph1 process.