Studies on muscle atrophy; a method of recording power in situ and observations on effect of position of immobilization on atrophy of disuse and denervation.
Studies on muscle atrophy; a method of recording power in situ and observations on effect of position of immobilization on atrophy of disuse and denervation.
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肌肉萎缩的研究；
DOI：
10.1001/archsurg.1945.01230040161003
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发表时间：
1945
影响因子：
--
通讯作者：
J. Key
中科院分区：
文献类型：
--
作者：
J. Eisenhauer;J. Key
这项工作的目的是确定两点：（1）四肢固定的最佳位置以保存肌肉力量；（2）治疗因神经供应丧失而瘫痪的肌肉的最佳方法。为了实现这一目标，有必要确定活体动物中给定肌肉的力量，然后在任意时间段内将这些肌肉固定在不同位置，最后解除固定并每隔一定时间测定肌肉的力量，以便了解固定的效果以及肌肉在使用后恢复正常的能力。完成此操作后，应对一系列肌肉进行去神经支配，以相同的方式进行治疗并接受各种类型的物理治疗。正如所言，问题看起来相对简单，我们满怀信心地进入了这个项目。我们这样做了
This work was undertaken in an attempt to determine two points: (1) the optimum position of fixation of limbs in order to conserve muscle power and (2) the best method of treatment of muscles paralyzed by loss of nerve supply. In order to accomplish this, it is necessary to determine the power of given muscles in living animals, then to immobilize these muscles in various positions over an arbitrary period and finally to remove the immobilization and determine the power in the muscles at intervals in order to learn the effect of the immobilization and the ability of the muscle to return to normal with use. This having been accomplished, a series of muscles should be denervated, treated in the same manner and subjected to various types of physical therapy. As it is stated, the problem seems relatively simple, and we entered on the project with confidence. This we did