Phosphatase and tensin homologue deleted on chromosome 10.
Phosphatase and tensin homologue deleted on chromosome 10.
复制标题
磷酸酶和Tensin同源物在染色体10上删除。
DOI：
10.4103/0300-1652.110033
复制
发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Blair M
中科院分区：
文献类型：
--
作者：
Abdulkareem IH;Blair M
10 号染色体上磷酸酶和张力蛋白同源物缺失 (PTEN) 是一种肿瘤抑制基因，在许多人类癌症中缺失或突变，例如胶质母细胞瘤、脊柱肿瘤、前列腺癌、膀胱癌、肾上腺癌、甲状腺癌、乳腺癌、子宫内膜癌和结肠癌。它们是由染色体 10q23 上的 PTEN 基因杂合性丢失 (LOH) 引起的。先前的研究报告称，各种药物、化学品和食物可以上调不同细胞系中 PTEN mRNA 和蛋白质的表达，它们可能有助于未来预防和/或治疗这些癌症。 PTEN 也被观察到具有预后意义，并逐渐被接受为独立的预后因素。这将有助于监测疾病进展和/或复发，以改善治疗结果并降低这些癌症的相关发病率和死亡率。脑啡肽酶 (NEP) 是一种锌依赖性金属肽酶，可裂解某些生物活性肽并使其失活，从而关闭细胞表面的信号转导。据报道，许多癌症中 NEP 表达降低。 NEP 可以与 PTEN 形成复合物，增强 PTEN 向质膜的募集并稳定其磷酸酶活性。 MicroRNA-21（miR-21）转录后下调PTEN的表达并刺激非小细胞肺癌（NSCLC）（肺Ca）的生长和侵袭，表明这可能是未来NSCLC治疗的潜在治疗靶点。 PTEN 是一种与许多人类癌症相关的肿瘤抑制基因。这在许多人类癌症的管理中具有诊断、治疗和预后意义，并且可能成为未来新药开发的目标。
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene deleted or mutated in many human cancers such as glioblastoma, spinal tumors, prostate, bladder, adrenals, thyroid, breast, endometrium, and colon cancers. They result from loss of heterozygosity (LOH) for the PTEN gene on chromosome 10q23. Previous studies reported that various drugs, chemicals, and foods can up-regulate PTEN mRNA and protein expression in different cell lines, and they may be useful in the future prevention and/or treatment of these cancers. PTEN has also been observed to have prognostic significance and is gradually being accepted as an independent prognostic factor. This will help in monitoring disease progression and/or recurrence, with a view to improving treatment outcomes and reducing the associated morbidity and mortality from these cancers. Neprilysin (NEP) is a zinc-dependent metallopeptidase that cleaves and inactivates some biologically active peptides thus switching off signal transduction at the cell surface. Decreased NEP expression in many cancers has been reported. NEP can form a complex with PTEN and enhance PTEN recruitment to the plasma membrane as well as stabilize its phosphatase activity. MicroRNA-21 (miR-21) post-transcriptionally down-regulates the expression of PTEN and stimulates growth and invasion in non-small cell lung cancer (NSCLC) (lung Ca), suggesting that this may be a potential therapeutic target in the future treatment of NSCLC. PTEN is a tumor suppressor gene associated with many human cancers. This has diagnostic, therapeutic, and prognostic significance in the management of many human cancers, and may be a target for new drug development in the future.