Prostaglandin synthesis inhibitors and vasa recta erythrocyte velocities in the rat.
Prostaglandin synthesis inhibitors and vasa recta erythrocyte velocities in the rat.
复制标题
前列腺素合成抑制剂和大鼠直肠血管红细胞速度。
DOI：
10.1152/ajprenal.1984.247.4.f562
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Jamison,RL
中科院分区：
文献类型：
--
作者：
Lemley,KV;Schmitt,SL;Holliger,C;Dunn,MJ;Robertson,CR;Jamison,RL
在暴露的肾乳头的麻醉水负荷大鼠的直血管红细胞速度（VRBC）之前和60分钟后静脉注射前列腺素合成抑制剂（吲哚美辛，甲氨蝶呤）或抑制剂的车辆单独测定。抑制剂组的升、降直血管VRBC变化[-17 +/-5%（SE）]与对照组（+12 +/-4%，P <0.002）不同。红细胞的速度也确定在抗利尿大鼠的直小血管前和30分钟后，给药吲哚美辛或车辆单独。与对照组相比，前列腺素合成抑制再次与VRBC显着下降相关（分别为-24 +/- 4%与+28 +/-20%，P小于0.025）。这些结果表明，在水利尿和抗利尿中，野牡丹素在调节肾髓质血流方面发挥相似的作用。
Vasa recta erythrocyte velocities (VRBC) in the exposed renal papilla of anesthetized water-loaded rats were determined before and 60 min after intravenous administration of a prostaglandin synthesis inhibitor (indomethacin, meclofenamate) or the inhibitor vehicle alone. The change in VRBC of ascending and descending vasa recta for the inhibitor group [-17 +/- 5% (SE)] was different from that for controls (+12 +/- 4%, P less than 0.002). Erythrocyte velocities were also determined in vasa recta of antidiuretic rats before and 30 min after administration of indomethacin or vehicle alone. Prostaglandin synthesis inhibition was again associated with a significant decrease in VRBC compared with control (-24 +/- 4% vs. +28 +/- 20%, respectively, P less than 0.025). These findings suggest that prostaglandins play a similar role in regulating blood flow in the renal medulla in water diuresis and antidiuresis.