The diffusional properties of dendrites depend on the density of dendritic spines.
The diffusional properties of dendrites depend on the density of dendritic spines.
复制标题
DOI：
10.1111/j.1460-9568.2011.07785.x
复制
发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Augustine GJ
中科院分区：
文献类型：
--
作者：
Santamaria F;Wils S;De Schutter E;Augustine GJ
We combined computational modeling and experimental measurements to determine the influence of dendritic structure on diffusion of intracellular chemical signals in mouse cerebellar Purkinje cells and hippocamal CA1 pyramidal cells. Modeling predicts that molecular trapping by dendritic spines causes diffusion along spiny dendrites to be anomalous and that the value of the anomalous exponent (dw) is proportional to spine density in both cell types. To test these predictions we combined local photorelease of an inert dye, rhodamine-dextran, with two-photon fluorescence imaging to track diffusion along dendrites. Our results show that anomalous diffusion is present in spiny dendrites of both cell types. Further, the anomalous exponent is linearly related to the density of spines in pyramidal cells and dw in Purkinje cells is consistent with such a relationship. We conclude that anomalous diffusion occurs in the dendrites of multiple types of neurons. Because spine density is dynamic and depends on neuronal activity, the degree of anomalous diffusion induced by spines can dynamically regulate the movement of molecules along dendrites.
登录
查看更多内容
影响因子：
3.4
作者：
SAXTON, MJ
通讯作者：
SAXTON, MJ
影响因子：
5.5
作者：
Schmidt, Hartmut;Kunerth, Svenja;Eilers, Jens
通讯作者：
Eilers, Jens
影响因子：
3.4
作者：
Vecellio, M;Schwaller, B;Celio, MR
通讯作者：
Celio, MR
影响因子：
64.8
作者：
Finch, EA;Augustine, GJ
通讯作者：
Augustine, GJ
影响因子：
2.4
作者：
Gal, Naama;Weihs, Daphne
通讯作者：
Weihs, Daphne