Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles.
Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles.
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DOI：
10.1371/journal.pone.0265852
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Gelfand EW
中科院分区：
文献类型：
--
作者：
Abbott JK;Chan SK;MacBeth M;Crooks JL;Hancock C;Knight V;Gelfand EW
尽管有充分的感染预防，但在整个静脉注射免疫球蛋白（IVIG）输注周期中自我报告的生活质量（QOL）变化是一种广泛报道但很少研究的现象。为了更好地理解这一现象，在3个输注周期内对接受IVIG替代剂量的体液免疫缺陷受试者进行了研究。收集了3个IVIG输注周期（输注日和每次输注后7天）6个时间点的问卷数据，并监测血液中调节性T细胞（Treg）数量和40种分泌分析物（主要是细胞因子、趋化因子和生长因子）的水平。在第7天，自我报告的幸福感增加，自我报告的疲劳减少，反映了输注后7天QOL的总体改善。在同一时期，血液中Treg细胞的百分比增加（p<0.01）。输注后1小时，血液中多种炎性趋化因子和细胞因子水平升高（CCL 4（MIP-1 B）、CCL 3（MIP-1a）、CCL 2（MCP-1）、TNF-α、颗粒酶B、IL-10、IL-1 RA、IL-8、IL-6、GM-CSF和IFN- γ）。分析物的最大变化发生在研究期间开始接受IVIG的受试者中。在入组研究前已接受常规输注的受试者中，在大多数时间间隔内观察到输注后IL-25（IL-17 E）显著降低。这些发现揭示了以替代剂量给予体液免疫缺陷患者的IVIG的几种短期效应：QOL在输注的第一周持续改善，输注后单核细胞相关细胞因子的集合水平立即增加，而IL-25水平降低，Treg水平增加。此外，新接受IVIG的患者比定期接受IVIG的患者细胞因子水平波动更大。
Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving replacement doses of IVIG were studied over 3 infusion cycles. Questionnaire data from 6 time points spread over 3 IVIG infusions cycles (infusion day and 7 days after each infusion) were collected in conjunction with monitoring the blood for number of regulatory T-cells (Treg) and levels of 40 secreted analytes: primarily cytokines, chemokines, and growth factors. At day 7, self-reported well-being increased, and self-reported fatigue decreased, reflecting an overall improvement in QOL 7 days after infusion. Over the same period, percentage of Treg cells in the blood increased (p<0.01). Multiple inflammatory chemokine and cytokine levels increased in the blood by 1 hour after infusion (CCL4 (MIP-1b), CCL3 (MIP-1a), CCL2 (MCP-1), TNF-α, granzyme B, IL-10, IL-1RA, IL-8, IL-6, GM-CSF, and IFN- γ). The largest changes in analytes occurred in subjects initiated on IVIG during the study. A significant decrease in IL-25 (IL-17E) following infusion was seen in most intervals among subjects already receiving regular infusions prior to study entry. These findings reveal several short-term effects of IVIG given in replacement doses to patients with humoral immunodeficiency: QOL consistently improves in the first week of infusion, levels of a collection of monocyte-associated cytokines increase immediately after infusion whereas IL-25 levels decrease, and Treg levels increase. Moreover, patients that are new to IVIG experience more significant fluctuations in cytokine levels than those receiving it regularly.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1084/jem.20140039
发表时间：
2014-09-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Perreau M;Vigano S;Bellanger F;Pellaton C;Buss G;Comte D;Roger T;Lacabaratz C;Bart PA;Levy Y;Pantaleo G
通讯作者：
Pantaleo G
影响因子：
7.3
作者：
Quinti, Isabella;Mitrevski, Milica
通讯作者：
Mitrevski, Milica
影响因子：
24.1
作者：
Maddur, Mohan S.;Trinath, Jamma;Bayry, Jagadeesh
通讯作者：
Bayry, Jagadeesh
影响因子：
5.8
作者：
Bates, Douglas;Maechler, Martin;Walker, Steven C.
通讯作者：
Walker, Steven C.