Different effects of ANP and nitroprusside on cyclic GMP extrusion of isolated aorta.
Different effects of ANP and nitroprusside on cyclic GMP extrusion of isolated aorta.
复制标题
ANP 和硝普钠对离体主动脉环 GMP 挤出的不同影响。
DOI：
10.1016/0014-2999(89)90321-x
复制
发表时间：
1989
影响因子：
5
通讯作者：
D. Neuser
中科院分区：
文献类型：
--
作者：
J. Stasch;S. Kazda;D. Neuser
心钠素(ANP)和硝普钠对去甲肾上腺素预收缩的兔主动脉具有明显的扩张作用。观察到两种血管扩张剂后，主动脉组织中环鸟苷酸明显升高。与硝普钠相反，ANP-(5-28)诱导剂量依赖的循环GMP从组织向介质中挤出。因此，环GMP的释放似乎是颗粒鸟苷环化酶激活的专一性的，并提供了一种除了合成和降解之外的机制，细胞可以通过这一机制来调节其内部的环GMP浓度。
Atrial natriuretic peptide (ANP) and sodium nitroprusside have potent vasodilator effects on the noradrenaline-precontracted isolated rabbit aorta. A distinct elevation of cyclic GMP in the aortic tissue was observed after both vasodilators. In contrast to sodium nitroprusside, ANP-(5–28) induced a dose-dependent cyclic GMP extrusion from the tissue into the medium. Thus, release of cyclic GMP appears to be specific for activation of particulate guanylate cyclase and provides a mechanism in addition to synthesis and degradation by which the cells can regulate their internal concentrations of cyclic GMP.