Plasma Surface Modification of Cyclo-olefin Polymers and Its Application to Lateral Flow Bioassays
Plasma Surface Modification of Cyclo-olefin Polymers and Its Application to Lateral Flow Bioassays
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DOI：
10.1021/la901455g
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发表时间：
2009-09-15
期刊：
影响因子：
3.9
通讯作者：
Killard, Anthony J.
中科院分区：
文献类型：
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作者：
Dudek, Magdalena M.;Gandhiraman, R. P.;Killard, Anthony J.
环烯烃聚合物Zeonor的改性等离子体增强化学气相沉积，形成一个类似二氧化硅的表面和评价其应用程序的侧流生物测定的应用进行了讨论，在这项研究中。使用接触角测量、原子力显微镜和衰减全内反射模式下的傅里叶变换红外光谱对SiO（x）层进行了广泛的表征，其中清楚地识别出均匀SiO（x）膜的存在。SiO（x）改性导致当与基于热压印微柱毛细管填充的基底组合时具有增强的润湿性和优异的流体性质的表面。SiO（x）表面还具有加速人血浆凝固的能力，这可能在某些类型的血液凝固测定中具有应用。
The modification of cyclo-olefin polymer Zeonor by plasma-enhanced chemical vapor deposition to form a silica-like surface and evaluation of its application for lateral flow bioassays applications are discussed in this study. The SiO(x) layer was extensively characterized using contact angle measurements, atomic force microscopy, and Fourier transform infrared spectroscopy in attenuated total internal reflectance mode where the presence of a uniform SiO(x) film was clearly identified. The SiO(x) modification resulted in a surface with enhanced wettability and excellent fluidic properties when combined with a hot-embossed micropillar capillary fill-based substrate. The SiO(x) surface also had the ability to accelerate the clotting of human plasma, which may have application in certain types of blood coagulation assays.