SUPPRESSION BY GLUCOCORTICOID OF THE IMMUNOREACTIVITY OF CORTICOTROPIN-RELEASING FACTOR AND VASOPRESSIN IN THE PARAVENTRICULAR NUCLEUS OF RAT HYPOTHALAMUS
SUPPRESSION BY GLUCOCORTICOID OF THE IMMUNOREACTIVITY OF CORTICOTROPIN-RELEASING FACTOR AND VASOPRESSIN IN THE PARAVENTRICULAR NUCLEUS OF RAT HYPOTHALAMUS
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DOI：
10.1016/0304-3940(87)90250-3
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发表时间：
1987-01-27
影响因子：
2.5
通讯作者：
SASANO, N
中科院分区：
文献类型：
--
作者：
ITOI, K;MOURI, T;SASANO, N
采用免疫细胞化学方法观察糖皮质激素对下丘脑室旁核促肾上腺皮质激素释放因子（CRF）和抗利尿激素分泌的影响。腹腔注射硫酸地塞米松（0.1 mg/d）可抑制双侧肾上腺切除术后大鼠PVH内侧细细胞分裂中CRF和加压素的免疫反应性。在大细胞分裂中，未观察到抗利尿激素免疫反应性的抑制。这些结果表明，抗利尿激素在内侧小细胞分裂中的作用与在大细胞分裂中的作用不同，前者在下丘脑-垂体-肾上腺轴中具有重要的功能意义。
The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.