Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia.
Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia.
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DOI：
10.1037//0021-843x.99.4.327
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发表时间：
1990-11
影响因子：
4.6
通讯作者：
Brett A. Clementz;John A. Sweeney;Michael Hirt;Gretchen L. Haas
中科院分区：
文献类型：
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作者：
Brett A. Clementz;John A. Sweeney;Michael Hirt;Gretchen L. Haas
对26例精神分裂症先证者、12例精神分裂症谱系亲属和46例非精神分裂症一级亲属以及38例非精神分裂症对照进行眼动功能评估。频谱亲属比非频谱亲属有更多的预期扫视（ASs）和更低的追求增益，而非频谱亲属比对照组有更多的预期扫视和更低的追求增益。先证者的追求增益也低于非谱系亲属和对照组，但在AS频率上与其他组没有差异。对照组受试者的整体追踪精度（均方根误差）高于两组，而先验者的均方根误差得分最低。方波激振频率不能区分各组。注意增强影响as的频率，但不影响其他侵入性跳眼事件或RMS评分。这些结果为眼动功能障碍可能作为精神分裂症的生物学标记提供了证据。
Oculomotor functioning of 26 probands with schizophrenia, 12 spectrum and 46 nonspectrum first-degree relatives, and 38 nonpsychiatric control subjects was evaluated. Spectrum relatives had more anticipatory saccades (ASs) and lower pursuit gain than nonspectrum relatives, who had more ASs and lower pursuit gain than control subjects. Probands also had lower pursuit gain than nonspectrum relatives and control subjects but did not differ from other groups on AS frequency. Control subjects had more globally accurate pursuit tracking (root mean square [RMS] error deviation) than both relative groups, whereas probands had the poorest RMS scores. Square wave jerk frequency did not differentiate the groups. Attention enhancement affected the frequency of ASs but did not affect either the other intrusive saccadic event or RMS scores. These results offer evidence that eye-movement dysfunction may serve as a biological marker for schizophrenia.