Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men
Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men
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DOI：
10.1001/archinte.164.10.1092
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发表时间：
2004-05-24
影响因子：
--
通讯作者：
Blair, SN
中科院分区：
文献类型：
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作者：
Katzmarzyk, PT;Church, TS;Blair, SN
背景资料：代谢综合征是一种普遍存在的疾病，它增加了2型糖尿病、心血管疾病（CVD）和死亡率的风险。目的：确定健康男性和代谢综合征患者心肺功能（CRF）与死亡率之间的关系。样本包括19223名年龄在20 - 83岁之间的男性，他们在1979年至1995年期间接受了临床评价，死亡率随访至1996年12月31日。结果：在196298人年的随访中，共有480例死亡（161例死于心血管疾病），其中健康男性15466例（80.5%），代谢综合征3757例（19.5%）。校正年龄、检查年份、吸烟状况、饮酒和父母CVD后，与健康男性相比，代谢综合征男性全因死亡率和CVD死亡率的相对危险度（RR）（95%置信区间）分别为1.29（1.05-1.57）和1.89（1.36-2.60）。纳入CRF后，相关性不显著。不健康与健康男性全因死亡率的RR为2.18（1.66-2.87），正常人为2.01（1.38-2.93），而不健康组与健康组的心血管死亡率RR分别为：健康男性和代谢综合征男性的健康男性分别为3.21（2.03-5.07）和2.25（1.27-3.97）。一个显着的剂量反应关系CRF和死亡率也观察到在男性代谢syndrome.Conclusion：在这个样本中，CRF提供了一个强大的保护作用，对全因和CVD死亡率在健康男性和男性代谢综合征。
Background: The metabolic syndrome is a prevalent condition that carries with it an increased risk of type 2 diabetes mellitus, cardiovascular disease (CVD), and mortality.Objective: To determine the relationship between cardiorespiratory fitness (CRF) and mortality in healthy men and in those with the metabolic syndrome.Methods: The sample included 19223 men, aged 20 to 83 years, who received a clinical evaluation between 1979 and 1995 with mortality follow-up through December 31, 1996. There were 15466 healthy men (80.5%) and 3757 men with the metabolic syndrome (19.5%).Results: A total of 480 deaths (161 due to CVD) occurred during 196 298 man-years of follow-up. After adjustment for age, year of examination, smoking status, alcohol consumption, and parental CVD, the relative risks (RRs) (95% confidence interval) of all-cause and CVD mortality were 1.29 (1.05-1.57) and 1.89 (1.36-2.60), respectively, for men with the metabolic syndrome compared with healthy men. After the inclusion of CRF, the associations were not significant. The RRs comparing unfit with fit men for all-cause mortality were 2.18 (1.66-2.87) in healthy men and 2.01 (1.38-2.93) in men with the metabolic syndrome, whereas the RRs for CVD mortality for unfit vs; fit men were 3.21 (2.03-5.07) in healthy men and 2.25 (1.27-3.97) in men with the metabolic syndrome. A significant dose-response relationship between CRF and mortality was also observed in men with the metabolic syndrome.Conclusion: In this sample, CRF provided a strong protective effect against all-cause and CVD mortality in healthy men and men with the metabolic syndrome.