Relationship of Monoamine Metabolites in Human Cerebrospinal Fluid to Age
Relationship of Monoamine Metabolites in Human Cerebrospinal Fluid to Age
复制标题
人脑脊液中单胺代谢物与年龄的关系
作者：
M. Bowers;F. Gerbode
已在动物和人脑脊液（CSF）中检测到5-羟色胺和多巴胺的代谢物高吗啉酸（HVA）和5-羟基吲哚乙酸（5 HIAA）（参考文献）。第1-3段）。虽然CSF中的这些物质可能来自中枢神经系统的神经元群体，但它们与脑功能改变的确切关系仍有待确定。尽管如此，多项临床研究报告称，某些患者群体的5 HIAA和HVA有所下降，特别是抑郁症精神病患者和帕金森病患者2 -4。在我们对CSF中单胺代谢物的研究过程中，我们发现这些物质的值随年龄而变化，无论是在精神病患者还是神经病患者中。这一发现可能对临床研究中CSF单胺代谢物值的解释至关重要。
HOMOVANILLIC acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA), metabolites of 5-hydroxytryptamine and dopamine, have been detected and measured in animal and human cerebrospinal fluid (CSF) (refs. 1–3). Although these substances in CSF probably derive from neuronal populations in the central nervous system, their precise relationship to altered brain function remains to be determined. Nevertheless, several clinical studies have reported a decrease in 5HIAA and HVA in certain groups of patients, notably depressed psychiatric patients and individuals suffering from Parkinsonism2–4. In the course of our studies on monoamine metabolites in CSF, we have found that values for these substances vary with age, both in psychiatric and neurological groups of patients. This finding may be crucial for the interpretation of values for CSF monoamine metabolites in clinical studies.