Diastereoselective hydroformylation of 2,5-cyclohexadienyl-1-carbinols with catalytic amounts of a reversibly bound directing group.
Diastereoselective hydroformylation of 2,5-cyclohexadienyl-1-carbinols with catalytic amounts of a reversibly bound directing group.
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DOI：
10.1021/ol1028546
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发表时间：
2011-01
期刊：
影响因子：
5.2
通讯作者：
I. Usui;K. Nomura;B. Breit
中科院分区：
文献类型：
--
作者：
I. Usui;K. Nomura;B. Breit
次膦酸酯作为可逆结合的导向基团，用于2，5-环己二烯基-1-甲醇的区域选择性和非对映选择性加氢。在两个烯烃官能团中，只有一个通过加氢官能化以形成合成上有吸引力的季碳中心，留下第二个烯烃官能团用于潜在的进一步官能化。
A phosphinite plays a role as a reversibly bound directing group for the regio- and diastereoselective hydroformylation of 2,5-cyclohexadienyl-1-carbinols. Of the two alkene functions only one was functionalized through hydroformylation to form a synthetically attractive quaternary carbon center leaving the second alkene function for potential further functionalization.