Morphine- and cocaine-induced c-Fos levels in Lewis and Fischer rat strains
Morphine- and cocaine-induced c-Fos levels in Lewis and Fischer rat strains
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DOI：
10.1016/j.brainres.2003.11.007
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发表时间：
2004-02-13
期刊：
影响因子：
2.9
通讯作者：
Riley, AL
中科院分区：
文献类型：
--
作者：
Grabus, SD;Glowa, JR;Riley, AL
据报道，刘易斯（LEW）和费舍尔344（F344）大鼠品系对可卡因和吗啡的奖赏和厌恶效应的敏感性不同。具体而言，LEW大鼠比F344大鼠更大程度地自我施用吗啡和可卡因，而LEW（与F344相比）大鼠对可卡因的厌恶效应更敏感，但对吗啡的厌恶效应不太敏感。与吗啡和可卡因在这两种品系中的奖励作用的评估一致，LEW大鼠在与奖励相关的脑区域中具有较低的基础活性，并且通常具有较高的药物诱导活性。虽然介导药物厌恶效应的大脑区域正在变得更好地定义，但没有研究比较LEW和F344品系中厌恶诱导药物对这些区域的激活。因此，药物激活这些厌恶相关脑区的能力与诱导这些品系中的条件性味觉厌恶（CTA）之间的关系尚不清楚。为了探索这种关系，LEW和F344大鼠注射生理盐水或剂量的吗啡或可卡因（两种药物均为32 mg/kg），这些药物已被证明在这些品系中产生不同的味觉厌恶学习。随后测试所有动物与厌恶学习（外侧和内侧臂旁核，中间和尾侧孤束核和最后区），奖励（背核的外壳）和运动（背核和尾壳核的核心）相关的大脑区域中的c-Fos表达。目前的研究结果表明，吗啡和可卡因诱导的c-Fos在CTA相关的，但不是奖励或运动相关的，脑区的模式，LEW和F344大鼠CTA学习这些药物的不同行为敏感性。分析其他药物，做和不诱导厌恶差异将进一步评估这些大脑区域在厌恶学习中的作用，一般来说，在应变依赖的差异，特别是。(C)2003 Elsevier B. V.保留所有权利。
Lewis (LEW) and Fischer 344 (F344) rat strains have been reported to differ in their sensitivity to the rewarding and aversive efffects of both cocaine and morphine. Specifically, LEW rats self-administer morphine and cocaine to a greater extent than F344 rats, while LEW (compared to F344) rats are more sensitive to the aversive effects of cocaine but less sensitive to the aversive effects of morphine. Consistent with assessments of the rewarding effects of morphine and cocaine in these two strains, LEW rats have lower basal, and generally higher drug-induced, activity in brain regions associated with reward. Although the brain areas that mediate the aversive effects of drugs are becoming better defined, no studies have compared the activation of these areas by aversion-inducing drugs in the LEW and F344 strains. As such, the relationship between the ability of drugs to activate these aversion-associated brain areas and to induce a conditioned taste aversion (CTA) in these strains is unknown. To explore this relationship, LEW and F344 rats were injected with saline or doses of morphine or cocaine (32 mg/kg for both drugs) that have been shown to generate differential taste aversion learning in these strains. All animals were subsequently tested for c-Fos expression in areas of the brain associated with aversion learning (the lateral and medial parabrachial nucleus, intermediate and caudal nucleus tractus solitarius and area postrema), reward (the shell of the nucleus accumbens) and locomotion (the core of the nucleus accumbens and the caudate putamen). The present results indicated that patterns of morphine- and cocaine-induced c-Fos within CTA-associated, but not reward- or locomotor-associated, brain regions paralleled the differential behavioral sensitivities of LEW and F344 rats to these drugs within CTA learning. Analyses with other drugs that do and do not induce aversions differentially would further assess the role of these brain areas in aversion learning, in general, and in strain-dependent differences, in particular. (C) 2003 Elsevier B.V. All rights reserved.