Hormonal control of the expression of antibody-defined lactosaminoglycans in the mouse uterus.
Hormonal control of the expression of antibody-defined lactosaminoglycans in the mouse uterus.
复制标题
小鼠子宫中抗体定义的乳糖胺聚糖表达的激素控制。
DOI：
10.1095/biolreprod39.3.699
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发表时间：
1988
影响因子：
3.6
通讯作者：
Hathaway,HJ
中科院分区：
文献类型：
--
作者：
Babiarz,BS;Hathaway,HJ
在发情期和妊娠早期，子宫经历了许多由子宫引起的变化。使用单克隆抗体SSEA-1、IIC 3、A5和C6研究了子宫糖蛋白群体的变化。这些抗体检测乳糖胺聚糖分子的特定末端或侧链修饰。在用雌激素处理的卵巢切除雌性小鼠中，SSEA-1是子宫上皮表达的唯一抗原。孕刺激2天诱导SSEA-1在子宫腺中的表达和A5在子宫上皮的唾液酸化形式。孕激素治疗三天诱导子宫腺内IIC 3的表达。孕酮治疗的额外一天导致IIC 3的子宫上皮表达。在自然交配的雌性中证实了这些抗原在孕前期的表达。在这些制剂中，从妊娠第2.0天开始，还观察到唾液酸化形式的C6表达。这些观察结果表明，微妙的修改乳糖胺聚糖链在子宫诱导的准备和接受阶段的小鼠子宫。
The uterus undergoes a number of hormone-induced changes during estrus and early pregnancy. Changes in the uterine glycoprotein population have been investigated by using the monoclonal antibodies SSEA-1, IIC 3, A5, and C6. These antibodies detect specific terminal or side-chain modifications of lactosaminoglycan molecules. In ovariectomized female mice treated with estrogen, SSEA-1 was the only antigen expressed at the uterine epithelium. Progestational stimuli for 2 days induced SSEA-1 expression in the uterine glands and the sialylated form of A5 at the uterine epithelium. Three days of progesterone treatment induced IIC3 expression within the uterine glands. An additional day of progesterone treatment resulted in a uterine epithelial expression of IIC3. The expression of these antigens in the progestational phase were confirmed in naturally mated females. In these preparations, expression of the sialylated form of C6 was also observed, beginning on Day 2.0 of gestation. These observations suggest subtle modification of lactosaminoglycan chains during the hormonally induced preparative and receptive phases of the mouse uterus.