Reduced response of cerebral blood flow to hypercapnia: Restoration by extracranial—intracranial bypass
Reduced response of cerebral blood flow to hypercapnia: Restoration by extracranial—intracranial bypass
复制标题
脑血流对高碳酸血症的反应降低：颅外-颅内旁路恢复
作者：
C. Bishop;K. Burnand;Marcus R. Brown;R. Russell;N. Browse
脑血流量，估计氙清除技术，已被用来研究8例患者的颅外-颅内（EC-IC）搭桥手术前后。还测量了脑血流对高碳酸血症的反应，以估计脑反应性，这是脑血管扩张储备能力的指标。所有患者的测量在手术后3个月重复。手术未增加静息脑血流量，但所有患者同侧半球的脑反应性均显著增加（P = 0.002）。在8名患者中，6名患者的对侧半球反应性也增加（P = 0.065）。脑血流对高碳酸血症的反应可能被证明在选择颈动脉闭塞或难以接近的狭窄的症状性患者进行EC-IC旁路血运重建时是有用的。
Cerebral blood flow, estimated by the xenon clearance technique, has been used to study eight patients before and after extracranial—intracranial (EC—IC) bypass surgery. Response of cerebral blood flow to hypercapnia was also measured to estimate cerebral reactivity, an indicator of cerebral vasodilator reserve capacity. Measurements in all patients were repeated 3 months after surgery. Resting cerebral blood flow was not increased by the operation but cerebral reactivity in the ipsilateral hemisphere was significantly increased in all patients (P = 0·002). Reactivity also increased in the contralateral hemisphere in six of the eight patients (P = 0·065). The response of cerebral blood flow to hypercapnia may prove useful in the selection of symptomatic patients with carotid occlusions or inaccessible stenoses for revascularization by EC—IC bypass.