Nationwide Results of COVID-19 Contact Tracing in South Korea: Individual Participant Data From an Epidemiological Survey
Nationwide Results of COVID-19 Contact Tracing in South Korea: Individual Participant Data From an Epidemiological Survey
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DOI：
10.2196/20992
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发表时间：
2020-08-01
影响因子：
3.2
通讯作者：
Yon, Dong Keon
中科院分区：
文献类型：
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作者：
Lee, Seung Won;Yuh, Woon Tak;Yon, Dong Keon
背景：关于新冠肺炎接触者追踪的有效性和相关的社会距离的证据有限，而且没有定论。目的：本研究旨在调查韩国SARS-CoV-2传播的流行病学特征，评估社会距离活动是否有效缓解COVID-19的传播。方法：我们使用合同追踪数据调查SARS-CoV-2在韩国传播的流行特征，评估社会距离活动是否有效缓解新冠肺炎的传播。我们计算了新冠肺炎感染类型(聚集性与非聚集性)的死亡率，并检验了新确认的新冠肺炎趋势在社会距离活动后是否发生了变化。结果：完成流行病学调查的2 537例确诊新冠肺炎患者中，聚集性病例1 305例(51.4%)，非聚集性病例1232例(48.6%)。与医疗机构和长期护理机构有关的聚集性病例死亡率(11/143，7.70%vs 5/1232，0.41%；调整后百分比差异7.99%；95%CI 5.83~10.14)和长期护理机构(19/221，8.60%vs 5/1232，0.41%；调整后百分比差异7.56%；95%CI 5.66~9.47)显著高于非聚集性病例。在整个队列(调整后趋势差为-2.28；95%CI为-3.88至-0.68)和聚集性感染组(调整后趋势差为-0.96；95%CI为-1.83至-0.09)中，新确诊新冠肺炎病例在社会疏远运动前后的趋势变化为显著负。结论：在韩国的一项全国性接触者追踪研究中，与医疗和长期护理设施相关联的新冠肺炎与非聚集性新冠肺炎相比显著增加了死亡风险。一项社会距离运动减少了新冠肺炎在韩国的传播，并对SARS-CoV-2的群集性感染产生了不同的影响。
Background: Evidence regarding the effectiveness of contact tracing of COVID-19 and the related social distancing is limited and inconclusive.Objective: This study aims to investigate the epidemiological characteristics of SARS-CoV-2 transmission in South Korea and evaluate whether a social distancing campaign is effective in mitigating the spread of COVID-19.Methods: We used contract tracing data to investigate the epidemic characteristics of SARS-CoV-2 transmission in South Korea and evaluate whether a social distancing campaign was effective in mitigating the spread of COVID-19. We calculated the mortality rate for COVID-19 by infection type (cluster vs noncluster) and tested whether new confirmed COVID-19 trends changed after a social distancing campaign.Results: There were 2537 patients with confirmed COVID-19 who completed the epidemiologic survey: 1305 (51.4%) cluster cases and 1232 (48.6%) noncluster cases. The mortality rate was significantly higher in cluster cases linked to medical facilities (11/143, 7.70% vs 5/1232, 0.41%; adjusted percentage difference 7.99%; 95% CI 5.83 to 10.14) and long-term care facilities (19/221, 8.60% vs 5/1232, 0.41%; adjusted percentage difference 7.56%; 95% CI 5.66 to 9.47) than in noncluster cases. The change in trends of newly confirmed COVID-19 cases before and after the social distancing campaign was significantly negative in the entire cohort (adjusted trend difference -2.28; 95% CI -3.88 to -0.68) and the cluster infection group (adjusted trend difference -0.96; 95% CI -1.83 to -0.09).Conclusions: In a nationwide contact tracing study in South Korea, COVID-19 linked to medical and long-term care facilities significantly increased the risk of mortality compared to noncluster COVID-19. A social distancing campaign decreased the spread of COVID-19 in South Korea and differentially affected cluster infections of SARS-CoV-2.