Veterans Aging Cohort Study (VACS) - Overview and description
Veterans Aging Cohort Study (VACS) - Overview and description
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DOI：
10.1097/01.mlr.0000223741.02074.66
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发表时间：
2006-08-01
期刊：
影响因子：
3
通讯作者：
Bryant, Kendall
中科院分区：
文献类型：
--
作者：
Justice, Amy C.;Dombrowski, Elizabeth;Bryant, Kendall
背景资料：退伍军人老龄化队列研究（VACS）是一项研究人类免疫缺陷病毒（HIV）感染和未感染的患者在传染病和一般医疗诊所。VACS包括早期的3和5研究中心研究（VACS 3和VACS 5）以及正在进行的8个研究中心的研究。目的：我们试图提供基于VACS数据的分析的背景和背景，包括研究设计和原理以及其基本方案和入选样本的基线特征。研究设计：我们进行了一项前瞻性同意的多地点观察性研究，研究对象是接受护理的退伍军人，有无艾滋病毒感染。数据来源于患者和提供者的自我报告、电话访谈、血液和DNA样本、焦点小组以及对国家VA“无纸化”电子病历系统的全面访问。超过7200名退伍军人至少参加了其中一项研究。8中心研究（VACS）入组了2979例HIV感染者和3019例HIV未感染者，年龄-人种-中心匹配的对照药物，截至2005年10月30日，达到了人种/种族和年龄分层入组目标，占总目标入组人数的99%。VACS的参与者与VA内接受护理的其他退伍军人相似。VACS参与者年龄较大，主要是黑人比疾病控制中心报告的。结论：VACS已经组装了一个丰富的，深入的，有代表性的样本的退伍军人在照顾和没有艾滋病毒感染进行纵向分析的问题，酒精使用和相关的共病和艾滋病定义条件之间的关联。
Background: The Veterans Aging Cohort Study (VACS) is a study of human immunodeficiency virus (HIV) infected and uninfected patients seen in infectious disease and general medical clinics. VACS includes the earlier 3 and 5 site studies (VACS 3 and VACS 5) as well as the ongoing 8 site study.Objectives: We sought to provide background and context for analyses based upon VACS data, including study design and rationale as well as its basic protocol and the baseline characteristics of the enrolled sample.Research Design: We undertook a prospectively consented multisite observational study of veterans in care with and without HIV infection.Measures: Data were derived from patient and provider self report, telephone interviews, blood and DNA samples, focus groups, and full access to the national VA "paperless" electronic medical record system.Results: More than 7200 veterans have been enrolled in at least one of the studies. The 8 site study (VACS) has enrolled 2979 HIV-infected and 3019 HIV-uninfected age-race-site matched comparators and has achieved stratified enrollment targets for race/ethnicity and age and 99% of its total target enrollment as of October 30, 2005. Participants in VACS are similar to other veterans receiving care within the VA. VACS participants are older and more predominantly black than those reported by the Centers for Disease Control.Conclusions: VACS has assembled a rich, in-depth, and representative sample of veterans in care with and without HIV infection to conduct longitudinal analyses of questions concerning the association between alcohol use and related comorbid and AIDS-defining conditions.