The genome, proteome and phylogenetic analysis of Sinorhizobium meliloti phage ΦM12, the founder of a new group of T4-superfamily phages
The genome, proteome and phylogenetic analysis of Sinorhizobium meliloti phage ΦM12, the founder of a new group of T4-superfamily phages
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DOI：
10.1016/j.virol.2013.11.027
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发表时间：
2014-02-01
期刊：
影响因子：
3.7
通讯作者：
Jones, Kathryn M.
中科院分区：
文献类型：
--
作者：
Brewer, Tess E.;Stroupe, M. Elizabeth;Jones, Kathryn M.
噬菌体Phi M12是苜蓿中华根瘤菌（Sinorhizobium meliloti）的重要转导噬菌体。在这里，我们报告的基因组，系统发育分析，和蛋白质组的Phi M12，第一次报告的基因组和蛋白质组的根瘤菌感染的T4超家族噬菌体。Phi M12的结构基因与蓝藻的T4-超家族C12最相似。Phi M12是第一个报道的T4超家族噬菌体，其缺乏编码I类核糖核苷酸还原酶（RNR）和核酸外切酶dexA的基因，并且具有II类辅酶B-12依赖性RNA。Phi M12的新基因集合使其成为一组新的T4超家族的创始人，融合了噬藻体和肠道细菌的特征。(C)2013作者爱思唯尔公司出版All rights reserved.
Phage Phi M12 is an important transducing phage of the nitrogen-fixing rhizobial bacterium Sinorhizobium meliloti. Here we report the genome, phylogenetic analysis, and proteome of Phi M12, the first report of the genome and proteome of a rhizobium-infecting T4-superfamily phage. The structural genes of Phi M12 are most similar to T4-superfamily phages of cyanobacteria. Phi M12 is the first reported T4-superfamily phage to lack genes encoding class I ribonucleotide reductase (RNR) and exonuclease dexA, and to possess a class II coenzyme B-12-dependent RNA. Phi M12's novel collection of genes establishes it as the founder of a new group of T4-superfamily phages, fusing features of cyanophages and phages of enteric bacteria. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.