The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD.
The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD.
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DOI：
10.1155/2014/476789
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发表时间：
2014
影响因子：
--
通讯作者：
Mancini A
中科院分区：
文献类型：
--
作者：
Borrelli A;Schiattarella A;Bonelli P;Tuccillo FM;Buonaguro FM;Mancini A
活性氧（ROS）是真核细胞线粒体中代谢反应的结果。这项工作描述了锰超氧化物歧化酶（MnSOD）作为不同人类疾病的生物标志物的作用，并提出了预防癌症及其治疗的新的治疗应用。本文还介绍了一种新形式的人MnSOD是如何发现的，它的初步应用，及其临床潜力。从人脂肪肉瘤细胞系（LSA）中分离的MnSOD能够杀死表达雌激素受体的癌细胞，但对正常细胞没有细胞毒性作用。重组MnSOD（rMnSOD）具有抗肿瘤活性，对X射线照射的正常细胞具有辐射防护作用。rMnSOD的特征在于存在前导肽，其允许蛋白质进入细胞：这种独特的性质可用于癌症或化疗的放射诊断，将放射性物质或化疗药物缀合到MnSOD的前导肽。与传统的化疗药物相比，与MnSOD的前导肽缀合的药物可以选择性地到达并进入癌细胞，从而减少传统治疗的副作用。
Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment. The paper also describes how a new form of human MnSOD was discovered, its initial application, and its clinical potentials. The MnSOD isolated from a human liposarcoma cell line (LSA) was able to kill cancer cells expressing estrogen receptors, but it did not have cytotoxic effects on normal cells. Together with its oncotoxic activity, the recombinant MnSOD (rMnSOD) exerts a radioprotective effect on normal cells irradiated with X-rays. The rMnSOD is characterized by the presence of a leader peptide, which allows the protein to enter cells: this unique property can be used in the radiodiagnosis of cancer or chemotherapy, conjugating radioactive substances or chemotherapic drugs to the leader peptide of the MnSOD. Compared to traditional chemotherapic agents, the drugs conjugated with the leader peptide of MnSOD can selectively reach and enter cancer cells, thus reducing the side effects of traditional treatments.
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DOI：
10.1046/j.1432-1327.2002.02840.x
发表时间：
2002-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Banci, L;Bertini, I;Viezzoli, MS
通讯作者：
Viezzoli, MS
影响因子：
20.3
作者：
Buschfort-Papewalis, C;Moritz, T;Thomale, J
通讯作者：
Thomale, J
影响因子：
6.1
作者：
Damiano, Sara;Trepiccione, Francesco;Capasso, Giovambattista
通讯作者：
Capasso, Giovambattista
影响因子：
6.4
作者：
BRAVARD, A;SABATIER, L;DUTRILLAUX, B
通讯作者：
DUTRILLAUX, B
影响因子：
3
作者：
Borrelli, Antonella;Schiattarella, Antonietta;Mancini, Aldo
通讯作者：
Mancini, Aldo