Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial
Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial
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DOI：
10.1177/0269881112473791
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发表时间：
2013-05-01
影响因子：
4.1
通讯作者：
Stough, Con
中科院分区：
文献类型：
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作者：
Pase, Matthew P.;Scholey, Andrew B.;Stough, Con
本研究旨在研究可可多酚对认知和情绪的急性和亚慢性影响。在一项随机、双盲研究中，健康的中年参与者接受了一种黑巧克力饮料混合物，标准化为含有500 mg、250 mg或0 mg多酚（安慰剂）。参与者每天服用一次分配的治疗药物，持续30天。认知与认知药物研究系统和自评情绪与邦德-莱德视觉焦虑量表。参与者在基线、单次急性给药后1、2.5和4小时以及接受30天治疗后再次接受测试。共有72名参与者完成了试验。30天后，与安慰剂相比，高剂量的治疗显著增加了自评的平静和满足感。情绪在急性给药后未发生变化，而认知在所有时间点均未受给药影响。这项随机对照试验可能是第一次证明可可多酚对健康参与者情绪的积极影响。这为探索可可多酚是否可以改善与临床焦虑或抑郁相关的症状提供了理论基础。
This study aimed to examine the acute and sub-chronic effects of cocoa polyphenols on cognition and mood. In a randomized, double-blind study, healthy middle-aged participants received a dark chocolate drink mix standardized to contain 500 mg, 250 mg or 0 mg of polyphenols (placebo) in a parallel-groups design. Participants consumed their assigned treatment once daily for 30 days. Cognition was measured with the Cognitive Drug Research system and self-rated mood with the Bond-Lader Visual Analogue Scale. Participants were tested at baseline, at 1, 2.5 and 4 h after a single acute dose and again after receiving 30 days of treatment. In total, 72 participants completed the trial. After 30 days, the high dose of treatment significantly increased self-rated calmness and contentedness relative to placebo. Mood was unchanged by treatment acutely while cognition was unaffected by treatment at all time points. This randomized controlled trial is perhaps the first to demonstrate the positive effects of cocoa polyphenols on mood in healthy participants. This provides a rationale for exploring whether cocoa polyphenols can ameliorate the symptoms associated with clinical anxiety or depression.