Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa
Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa
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DOI：
10.1099/0022-1317-78-4-847
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发表时间：
1997-04-01
影响因子：
3.8
通讯作者：
Gompels, UA
中科院分区：
文献类型：
--
作者：
Kasolo, FC;Mpabalwani, E;Gompels, UA
最近描述了新的疱疹病毒。这些病毒包括人类疱疹病毒6、7和8(HHV-6、-7、-8)，HHV-6至少有两个毒株组，变种A和B。B毒株在西方占主导地位，可占婴儿感染的97%以上。相比之下，A型毒株很少见，少数几个特征良好的分离株来自非洲成年艾滋病患者。目前尚不清楚HHV-6变种A毒株是否与艾滋病有关，以及/或者它们是否也可以在童年感染时获得，并可能在成年后重新激活。地理差异起到了什么作用还有待评估。HHV-8与艾滋病相关的流行卡波西氏肉瘤(KS)有关，但也在地方性KS中被发现。在KS流行的非洲地区，艾滋病的发作导致KS的流行增加。在这份报告中，我们在艾滋病流行和KS流行地区赞比亚检查了这些新型疱疹病毒在婴儿期的感染情况。在首次发热的人类免疫缺陷病毒阴性婴儿的血液样本中，半定量PCR和序列分析同时检测到8%的HHV-8和30%的HHV-6，其中44%的变异A；在儿童地方性KS活检中，HHV-8的阳性率为100%，HHV-6的阳性率为0。婴儿血液样本中的高病毒DNA载量与病毒血症相一致。这是首次证明HHV-6变种A和HHV-8可能作为常见的儿童感染而获得。
Novel herpesviruses have been described recently. These include human herpesviruses 6, 7 and 8 (HHV-6, -7, -8), HHV-6 has at least two strain groups, variants A and B. The B strains are predominant in the West and can account for over 97% of infections in infants. In contrast, the A strains are rare and the few well-characterized isolates have been from adult African AIDS patients. It is not clear whether the HHV-6 variant A strains are AIDS-related and/or whether they can also be acquired as childhood infections and may reactivate later during adulthood. What contribution geographical variation plays has yet to be assessed. HHV-8 has been associated with AIDS-related epidemic Kaposi's sarcoma (KS), but has also been identified in endemic KS. In regions of Africa where KS is endemic, the onset of AIDS has led to increased prevalence of KS. In this report, we examine in Zambia, an AIDS epidemic and KS endemic region, infection with these novel herpesviruses during infancy. In blood samples from human immunodeficiency virus-negative infants with first febrile episode, both semi-quantitative PCR and sequence analyses were used to identify HHV-8 in 8% and HHV-6 in 30%, with 44% of these variant A; in childhood endemic KS biopsies HHV-8 was detected in 100% and HHV-6 in none. The high viral-DNA loads in the infant blood samples were consistent with viraemia. This is the first demonstration that HHV-6 variant A and HHV-8 may be acquired as common childhood infections.