Phasic pupil dilation response to noxious stimulation in normal volunteers: Relationship to brain evoked potentials and pain report
Phasic pupil dilation response to noxious stimulation in normal volunteers: Relationship to brain evoked potentials and pain report
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DOI：
10.1017/s0048577299970373
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发表时间：
1999-01-01
期刊：
影响因子：
3.7
通讯作者：
Donaldson, GW
中科院分区：
文献类型：
--
作者：
Chapman, CR;Oka, S;Donaldson, GW
研究了男性 (n = 11) 和女性 (n = 9) 的瞳孔对有害刺激的反应。受试者反复尝试四种强度的有害指尖电刺激，从微弱的疼痛到几乎无法忍受的疼痛。测量指标包括瞳孔扩张反应 (PDR)、疼痛报告 (PR) 和脑诱发电位 (EP)。 PDR 在刺激后 0.33 秒开始，并在 1.25 秒达到峰值。多变量混合效应分析显示，(a) 随着刺激强度的增加，PDR 的峰值幅度显着增加；(b) 150 和 250 ms 处的 EP 峰值在刺激强度范围内的幅度和潜伏期显着不同；(c) PR 随着刺激强度的增加而显着增加。男性表现出明显高于女性的 EP 峰值振幅和 150 毫秒峰值潜伏期。在部分排除性别和刺激强度影响的情况下，150 ms 的 EP 峰值潜伏期显着预测 PR，150 ms 的 EP 峰值幅度显着预测 PDR 峰值幅度。
Pupillary response to noxious stimulation was investigated in men (n = 11) and women (n = 9). Subjects experienced repeated trials of noxious electrical fingertip stimulation at four intensities, ranging from faint to barely tolerable pain. Measures included pupil dilation response (PDR), pain report (PR), and brain evoked potentials (EPs). The PDR began at 0.33 s and peaked at 1.25 s after the stimulus. Multivariate mixed-effects analyses revealed that (a) the PDR increased significantly in peak amplitude as stimulus intensity increased, (b) EP peaks at 150 and 250 ms differed significantly in both amplitude and latency across stimulus intensity, and (c) PR increased significantly with increasing stimulus intensity. Men demonstrated a significantly greater EP peak amplitude and peak latency at 150 ms than did women. With sex and stimulus intensity effects partialled out, the EP peak latency at 150 ms significantly predicted PR, and EP peak amplitude at 150 ms significantly predicted the PDR peak amplitude.